Issues

Summary: Collective cell migration is key to morphogenesis and metastasis. Advances in imaging and modelling reveal how cells interact with each other and their environment, shaping their migration behaviours.

Summary: A review of desmosome structure and assembly, highlighting recent insights into how desmosomes integrate signaling in the epidermis, and an overview of desmosomes as targets in human disease.

Highlighted Article: The plant division site protein TANGLED1 is recruited to de novo cell plate insertion sites independently of the preprophase band.

Summary: Lomustine induces stress granules that sequester EGR1 mRNA, inhibiting its translation, thereby reducing apoptosis and enhancing cell survival during chemotherapy.

Summary: Insertion of loxP sites around exon2 of the Hif-2a gene unintendedly reduced the expression of the Atp4v1e2 gene located 147 kbp away. This revealed a prominent role of the vacuolar ATPase for Friend virus spread.

Highlighted Article: Nitrogen has a general positive effect on mitotic fidelity in fission yeast and indirectly suppresses catastrophic mitosis in lipid metabolism mutants.

Highlighted Article: Little is known about the maintenance of adult neural circuits. Continuous expression of Fasciclin 3, a cell adhesion protein involved in axon guidance, is required for neuronal survival in the adult fly olfactory circuit.

Summary: KRAP regulates transfer of Ca²⁺ from IP₃ receptors to mitochondria by both stabilizing membrane contact sites between the ER and mitochondria and licensing IP₃ receptors to respond to IP₃ at these junctions.

Highlighted Article: Cells migrating through confined 3D spaces contract their rear cortex using RhoA-mediated myosin activity to generate increased pressure in the back compartment that drives the nucleus through the constriction.