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RESEARCH HIGHLIGHTS

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CELL SCIENTISTS TO WATCH

OPINION

Summary: Solutions to improve the accessibility of scientific conferences are proposed, including designated accessibility officers, accessibility checklists and measures to avoid personal disclosures of disability.

REVIEW

Summary: Cancer cell proliferation and tumorigenesis rely on adaptations in membrane trafficking, which play crucial roles in nutrient availability, metabolic regulation and resistance to therapy as reviewed here.

SHORT REPORTS

Summary: Zika virus (ZIKV) pose an increasing threat to human health. We reveal an unforeseen function of host cell caveolin-1 in facilitating ZIKV replication.

Summary: Positively charged amino acid motifs target Yurt to the lateral membrane via electrostatic interaction with phosphoinositides to support epithelial tissue morphogenesis in D. melanogaster embryos.

RESEARCH ARTICLES

Summary: We identify and characterise 30 transition fibre proteins in Trypanosoma brucei, showing that transition fibres are complex and dynamic structures with roles in flagellum assembly and length regulation.

Highlighted Article: We have developed mature hepatocyte organoid cultures that allow studies of various metabolic functions characteristic of adult mouse and human livers in vitro.

Summary: SARS-CoV-2 limits T cells activation by reducing MHC II expression on antigen-presenting cells. This suppression of MHC II occurs via inactivation of the CIITA promoter by a complex of viral NSP5 and host IRF3 and HDAC2.

Highlighted Article: We show that TAZ and YAP play divergent roles in astrocyte differentiation, with YAP regulating cell cycle states of progenitor cells and TAZ regulating fate specification and maturation.

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