Issues
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Cover image
Cover Image
Cover: MCF10A cells overexpressing vimentin. The cells are labelled with phalloidin (red), anti-vimentin antibodies (green) and DAPI (blue). See article by A. I. Fokin et al. (jcs261332).
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RESEARCH HIGHLIGHTS
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Characterizing chromosomal instability-driven cancer evolution and cell fitness at a glance
Summary: We discuss the relationship between chromosomal instability, cancer cell fitness and tumour evolution, and describe techniques that can be used to explore the relationship between these factors.
OPINION
Believing is seeing – the deceptive influence of bias in quantitative microscopy
Summary: Microscopy requires many decisions about experimental design, acquisition and analysis, and each choice is prone to human bias. We describe how each step must be carefully considered for scientific rigor.
REVIEW
Cristae shaping and dynamics in mitochondrial function
Summary: Mitochondrial cristae are now known to be a dynamic compartment. Here, we discuss the current knowledge of cristae architecture and protein dynamics, together with methodological approaches for their investigation.
SHORT REPORT
A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network
Summary: Signalling by the S. pombe septation initiation network, which regulates cytokinesis, responds to the change from aerobic fermentation to growth by respiration through reduction of protein kinase A activity.
RESEARCH ARTICLES
Stiffness-dependent MSC homing and differentiation into CAFs – implications for breast cancer invasion
Highlighted Article: The findings of this research suggest that homing of MSCs at the pre-metastatic stage and their subsequent differentiation into CAFs actively drives breast cancer invasion and metastasis in TNBCs.
The Small Interactor of PKD2 protein promotes the assembly and ciliary entry of the Chlamydomonas PKD2–mastigoneme complexes
Summary: Small Interactor of PKD2 (SIP) is a novel, single-transmembrane-helix PKD2-related protein that is a crucial part of the ciliary PKD2–mastigoneme complex in Chlamydomonas.
Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration
Highlighted Article: A super-migrator cell line was obtained upon inactivation of three negative regulators of cortical branched actin (arpin, ARPC1A and CYFIP2). Its exceptional motile behavior is associated with changes in gene expression.
The role of microtubule-associated protein tau in netrin-1 attractive signaling
Summary: The microtubule-associated protein tau directly links the netrin/DCC signaling pathway to dynamic microtubules in the neuronal growth cone to promote axon outgrowth, branching and attraction.
FIRST PERSON
Call for papers: Cell Biology of Mitochondria
We are welcoming submissions for our upcoming special issue: Cell Biology of Mitochondria. This issue will be coordinated by two Guest Editors: Ana J. Garcia-Saez (University of Cologne, Germany) and Heidi McBride (McGill University, Canada). Submission deadline: 1 October 2024.
Focal adhesion kinase signalling – tumour vulnerabilities and clinical opportunities
In this Review, David Schlaepfer and colleagues summarise 30 years of focal adhesion kinase (FAK) research with a view of the ongoing clinical testing of small-molecule FAK inhibitors. The authors touch on how FAK plays an important signal integration role and ultimately functions to guide cellular behaviour. Additionally, the authors discuss how FAK inhibition might present a powerful tool to influence the physiological response to other therapeutic approaches.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2024 applications: 7 September (decision by week commencing 8 October 2024); 22 November (decision by week commencing 16 December).
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK.
Interview with Journal of Cell Science Editor Rob Parton
Read our interview with Rob Parton, a Cell Scientist to Watch, about his career journey leading him from the UK to the University of Queensland in Brisbane, Australia, the evolution of the membrane trafficking field and his advice for running a highly collaborative lab. As a Journal of Cell Science Editor, Rob brings to the journal his expertise in multiscale analysis of membrane function, membrane microdomains, lipid droplets and advanced microscopy techniques in cell biology.