Issues

Summary: We discuss the relationship between chromosomal instability, cancer cell fitness and tumour evolution, and describe techniques that can be used to explore the relationship between these factors.

Summary: Microscopy requires many decisions about experimental design, acquisition and analysis, and each choice is prone to human bias. We describe how each step must be carefully considered for scientific rigor.

Summary: Mitochondrial cristae are now known to be a dynamic compartment. Here, we discuss the current knowledge of cristae architecture and protein dynamics, together with methodological approaches for their investigation.

Summary: Signalling by the S. pombe septation initiation network, which regulates cytokinesis, responds to the change from aerobic fermentation to growth by respiration through reduction of protein kinase A activity.

Highlighted Article: The findings of this research suggest that homing of MSCs at the pre-metastatic stage and their subsequent differentiation into CAFs actively drives breast cancer invasion and metastasis in TNBCs.

Summary: Small Interactor of PKD2 (SIP) is a novel, single-transmembrane-helix PKD2-related protein that is a crucial part of the ciliary PKD2–mastigoneme complex in Chlamydomonas.

Highlighted Article: A super-migrator cell line was obtained upon inactivation of three negative regulators of cortical branched actin (arpin, ARPC1A and CYFIP2). Its exceptional motile behavior is associated with changes in gene expression.

Summary: The microtubule-associated protein tau directly links the netrin/DCC signaling pathway to dynamic microtubules in the neuronal growth cone to promote axon outgrowth, branching and attraction.