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RESEARCH HIGHLIGHTS

EDITORIAL

JCS PRIZE

REVIEWS

Summary: Key recent advances in our understanding of crinophagy – the direct fusion of secretory granules with lysosomes – and related degradation pathways are discussed, including potential links to disease.

Summary: Talin is a key protein controlling integrin-dependent cell–matrix adhesions. Here, we summarize its function in linking mechanical coupling to the actin cytoskeleton and adhesion signaling.

SHORT REPORT

Summary: Calcineurin phosphatase participates in regulation of the centrosome and cilia. Calcineurin localizes to centrioles, where it interacts with POC5, and inhibition of calcineurin promotes elongation of cilia.

RESEARCH ARTICLES

Summary: Live-cell imaging reveals that DNA-dependent protein kinase, but not ATM, plays a primary role in the phosphorylation of histone H2AX during the immediate early response to DNA damages.

REVIEW COMMONS TRANSFER

Highlighted Article: Using a bio-probe, we show that Rho1 is activated in late cytokinesis, just prior to septum ingression in fission yeast. We find that Cdc42 prevents premature Rho1 activation during early cytokinesis.

Highlighted Article: In this biochemical study, we show that talin and kindlin cooperate to mediate the formation of large integrin clusters. In this process, kindlin imposes protein density and promotes integrin–talin–actomyosin coupling.

REVIEW COMMONS TRANSFER

Summary: Although cholesterol-dependent cytolysins, such as streptolysin O, are resisted primarily by MEK-dependent shedding, the small pore-forming toxin aerolysin is resisted by Ca2+-dependent patch repair.

Summary: SLC25A46 loss of functions mutations underlies a number of neurological syndromes; we propose that SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in insulin-secreting cells.

TOOLS AND RESOURCES

Summary:We reveal new insights into the transcriptional specialization of myotendinous junction myonuclei and their association with protein expression in healthy human muscle–tendon tissue.

Summary: New tools and resources are available for generating tight two-gene on–off switches in mammalian cells.

FIRST PERSON

PUBLISHER'S NOTE

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