Issues

Summary: Discover how to apply the latest genetically encoded imaging tools to examine the dynamic cell function that you are most interested in.

Summary: A discussion of the recent studies that have established histone N-terminal acetylation as an epigenetic modification involved in multiple cellular phenotypes.

Highlighted Article: Instead of acting as a p53 transcriptional target, ISG20L1 functions as a co-activator of DAPK1 to induce p53 transactivation and mediate p53 dependent apoptosis in human cancer cell lines.

Summary: Our combination of super resolution microscopy and cryo-soft X ray tomography provides fundamental insights into how septin cage entrapment of Shigella is coordinated with ubiquitin-mediated autophagy.

Summary: We unravel determinants of plasma membrane localization of the Na⁺,HCO₃⁻ co-transporter NBCn1 and discover its dynamic localization to centrosomes, midbody, spindle and primary cilia.

Summary: The human CHD4 protein has a single nuclear localization signal in the N-terminus of the protein and has already assembled into the core NuRD complex in the cytoplasm.

Highlighted Article: Activity-induced palmitoylation of synaptic proteins is important for synapse plasticity and is mediated through post-translational modification of the ZDHHC palmitoylating enzymes.

Summary: The Drosophila chondroitin sulfate proteoglycan Windpipe finetunes heparan sulfate-dependent morphogen signaling, indicating a close functional relationship between chondroitin sulfate and heparan sulfate.

Summary: We studied the biochemical and dynamic properties of the testis-specific SUN domain protein SUN4 and provide novel insights into its interaction behavior at the spermatid nucleo-cytoplasmic junction.

Summary: The role of membrane rafts in EGFR signaling may be context specific. We find that the related receptor HER2 defines unique requirements for membrane rafts, flotillin and c-Src in EGFR signaling.