Issues

Summary: A Review of ubiquitylation and its biochemical relatives as regulators of the endolysosomal system and its hijacking by intracellular bacteria in order for them to prosper inside cells.

Summary: The complex diffusion behaviors of various transmembrane proteins in Dictyostelium cells can be explained quantitatively by free diffusion on three membrane regions of different viscosities.

Summary: Chromosome compaction depends on the cell cycle and the chromosome arm. In vivo, chromatin dynamics, which are modulated by transcription and interactions between chromatin and nuclear landmarks, are genomic-locus specific.

Highlighted Article: Phosphorylation of nuclear lamin A/C at Ser22 is an evolutionarily conserved mechanism that regulates lamin dynamics to serve nuclear adaptation and cell survival in heat-shocked cells.

Highlighted Article: Nucleolar architecture is altered during myogenic differentiation, indicating that the phase separation properties and function of the nucleolus might change during myogenesis.

Summary: The parasitophorous vacuole of Toxoplasma gondii sequesters host organelles by utilizing TgGRA14 and TgGRA64, which interact with host ESCRT proteins for vacuolar membrane remodeling and fission.

Highlighted Article: The C-terminal region of Jaw1, a tail-anchored protein, is cleaved by the signal peptidase complex and this cleavage event enhances the augmentative effect of Jaw1 on the Ca²⁺ release activity of inositol 1,4,5-trisphosphate receptors.

Summary: Fast4DReg is an open-source Fiji plugin that can quickly correct axial and lateral drift in multidimensional microscopy datasets.