Issues
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Cover image
Cover Image
Cover: Confocal image depicting a SKOR1-mutant triple-negative breast cancer cell. The image has been stylised using the Oil Paint filter in Adobe Photoshop. Focal adhesions and the heart-shaped nucleus are highlighted in red, and the homogenous cytoplasmic distribution of overexpressed mutant SKOR1 is shown in green. SKOR1-mutant cells exhibit a non-invasive phenotype, including extensive cell spreading and abundant focal adhesion sites, which is in clear contrast to the well-known aggressive phenotype of the parental triple-negative breast cancer cells. See article by L. M. Sluimer et al. (jcs260243).
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RESEARCH HIGHLIGHTS
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CELL SCIENTISTS TO WATCH
REVIEWS
Ciliary mechanosensation – roles of polycystins and mastigonemes
Summary: Polycystin channels reside on cilia of cells in many important tissues, and polycystin mutations can lead to polycystic kidney disease. Here, we review working models describing ciliary polycystin function.
Structure and function of distal and subdistal appendages of the mother centriole
Summary: A review of the composition and assembly of centriolar appendages, as well as their roles in development and disease.
RESEARCH ARTICLES
DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs
Highlighted Article: Dominant-negative mutations in DRP1 identified in patients with EMPF1 result in mitochondrial and peroxisomal hyperfusion, severe alterations in mitochondrial membrane potential and metabolic reprograming.
Intravital imaging of Wnt/β-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis
Summary: Using intravital imaging and an avian embryo xenograft model, we show that canonical Wnt and ATF2 signalling pathways have complementary activity patterns during human cancer cell invasion and metastasis.
ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy
Summary: The SNARE protein YKT6 plays a conserved role in autophagosome formation and fusion with lysosomes, which is controlled by the ULK1 kinase.
Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions
Summary: The Pil1 homolog Lsp1 is sufficient for eisosome assembly under various types of membrane stress in yeast. Eisosome assembly is connected to respiration, the TCA cycle, DNA repair, ribosome biogenesis and cell cycle.
The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery
Summary: COPII vesicle formation and trafficking of plasma membrane proteins depend on the phosphorylated state of S134 in Erv14
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells
Summary: Ski family transcriptional corepressor 1 (SKOR1), which has been mainly associated with neuronal development, is a direct substrate of the oncogenic tyrosine kinase FER and a driver of triple-negative breast cancer progression.
Dynamics of intracellular cGMP during chemotaxis in Dictyostelium cells
Highlighted Article: Propagating waves of intracellular cGMP were visualized in chemotactic Dictyostelium cells with a fluorescent probe. Increased intracellular cGMP levels induced a transient shuttle of myosin II between the cytosol and cell cortex.
Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis
Highlighted Article: Mitotic fidelity in the fission yeast S. pombe, which undergoes closed mitosis, requires diacylglycerol consumption fueling a spike in glycerophospholipid biosynthesis to enable nuclear membrane expansion.
CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins
Summary: The primary cilium is a microtubule-based organelle that acts as a signaling nexus. The ciliopathy-linked protein CCDC66 is required for assembling signaling-competent cilia with proper structure and size.
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Call for papers - Cilia and Flagella: from Basic Biology to Disease

We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The final deadline for registration is 28 February 2025.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
How to investigate GPCR signalling in cells

Abigail Pearce and colleagues provide a critical overview of new, state-of-the-art approaches used to quantitatively study G protein-coupled receptor signalling in cells.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).