Issues

Summary: In this Cell Science at a Glance poster, we summarize current knowledge of the functional and structural characterizations of actin-based protrusions, with a focus on filopodia, cytonemes and tunneling nanotubes.

Summary: A review of the molecular mechanism of MOMP, with a focus on recently discovered roles of BCL-2 proteins in apoptosis and beyond, including what implications these might have in both healthy tissues and disease.

Summary: The antiproliferative effect of FGF2 in an oncogenic cell model modulates transcription, particularly rRNA expression, promotes nucleolus disorganization and directly modulates the proteome of the rDNA loci.

Summary: We utilise the spherical aberration of the objective lens in bright-field imaging to reveal that the human spermatozoon head rotates in a counterclockwise direction, as viewed from head to tail.

Summary: The insulin–mTORC1 growth axis is defective in individuals with SLOS, who have a cholesterol biosynthesis disorder. The defect can be corrected in cells by supplementing cholesterol or by activating Rag GTPase.

Highlighted Article: In the ciliate Tetrahymena thermophila, four proteins are shown to provide markers for different zones of the contractile vacuole complex and, hence, enable in vivo analysis of its dynamics.

Highlighted Article: Microtubules under mechanical pressure can breach dense actin networks solely based on their polymerization forces. Mechanical pressure can be induced by mechanical hindrance or by using crosslinkers.

Highlighted Article: Changes in the cholesterol content of presynaptic terminals play critical roles in the development and plasticity of Drosophila larval neuromuscular junctions.

Summary: A protocol for investigating the Plasmodium liver stage that involves the expansion of pre-stained samples, leading to a significantly expedited procedure, and enhanced preservation of specific epitopes.