CELL SCIENTISTS TO WATCH
Summary: In this Review we briefly summarize the basis for the development of nanobodies and provide an overview of the multiple applications of these versatile binders in biological research.
Summary: SETD2 catalyses trimethylation of lysine 36 on histone H3. Here, we review the roles of SETD2 in mammals, with a focus on the central nervous system, and summarise the consequences of pathogenic SETD2 variants in humans.
Characterization of Pik1 function in fission yeast reveals its conserved role in lipid synthesis and not cytokinesis
Summary: Fission yeast Pik1 localizes exclusively to the trans-Golgi independently of Ncs1, where it contributes to PI4P but not PI(4,5)P2 synthesis. Pik1 does not affect cytokinesis.
Highlighted Article: In C. elegans, nuclear closure around spindle microtubules requires BAF-1 binding to LEM-domain proteins and reveals redundant and unique functions for EMR-1, LEM-2 and CHMP-7 in nuclear maintenance.
Palmitate-induced insulin resistance causes actin filament stiffness and GLUT4 mis-sorting without altered Akt signalling
Highlighted Article: Saturated fats elicit muscle cell-autonomous dysregulation of the basal-state machinery required for the GLUT4 translocation that ‘primes’ skeletal muscle cells for insulin resistance.
Summary: Defects in centrosome organization (centriole number and length) are imparted by MCPH-associated mutations in the CPAP G-box domain, which impacts spindle organization and cell survival.
Centrosome amplification promotes cell invasion via cell–cell contact disruption and Rap-1 activation
Summary: Centrosome amplification is sufficient, without additional pro-oncogenic alterations, to drive early tumorigenic change in a normal breast epithelial background.
The SUN-like protein TgSLP1 is essential for nuclear division in the apicomplexan parasite Toxoplasma gondii
Summary: Identification of a SUN-like protein in the apicomplexan parasite Toxoplasma gondii that is essential for replication.