Issues
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Cover image
Cover Image
Cover: Age-induced polyploidy arises by cell fusion. Bicolored epithelial cells (pink) form via the fusion of yellow and magenta labelled cells in 40-day-old flies. Epithelial cell borders are labelled with a septate junction protein in cyan. See article by A. S. Dehn et al. (jcs260974).
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RESEARCH HIGHLIGHTS
STICKY WICKET
CELL SCIENTISTS TO WATCH
OPINION
Upregulation of fibronectin and its integrin receptors – an adaptation to isolation stress that facilitates tumor initiation
Summary: We summarize how tumor cells upregulate LPAR4, fibronectin and two fibronectin-binding integrins, α5β1 and αvβ3, to promote stress tolerance, cancer stemness and tumor initiation.
REVIEW
Atypical MAP kinases – new insights and directions from amoeba
Summary: A Review on the current understanding of MAPK15-related atypical MAPK function and regulation, highlighting how studies in amoeba have provided information on atypical MAPK roles in chemotaxis and gene regulation.
RESEARCH ARTICLES
Transcription inhibition suppresses nuclear blebbing and rupture independently of nuclear rigidity
Highlighted Article: Inhibitors of transcription suppress both nuclear bleb formation and stabilization without altering nuclear rigidity, actin compression or actin contraction, suggesting new biophysics for nuclear morphology.
Phosphorylation of axin within biomolecular condensates counteracts its tankyrase-mediated degradation
Highlighted Article: Within biomolecular condensates the Wnt pathway regulator axin is N-terminally phosphorylated by CK1α, which impairs axin–tankyrase interaction and protects axin from tankyrase-mediated degradation.
Characterisation of TbSmee1 suggests endocytosis allows surface-bound cargo to enter the trypanosome flagellar pocket
Summary: Characterisation of TbSmee1, and subsequent comparison with clathrin depletion, suggests that surface-bound cargo can only enter the trypanosome flagellar pocket when endocytosis is active.
Vimentin intermediate filaments provide structural stability to the mammalian Golgi complex
Summary: Vimentin intermediate filaments associate with the trans-Golgi network protein GORAB and provide structural stability to the Golgi complex in mammalian cells.
Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors
Summary: A rapid time-resolved proximity biotinylation approach to identify novel candidates that facilitate the export of membrane proteins in the P. falciparum-infected red blood cell.
Epithelial mechanics are maintained by inhibiting cell fusion with age in Drosophila
Highlighted Article: Polyploid cells arise with age through a cell fusion process, leading to a decline in the biomechanical fitness of the fruit fly.
FIRST PERSON
PUBLISHER’S NOTE
CORRECTION
JCS fast-track option
Have a paper that has been reviewed elsewhere? JCS is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision within one week.
Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Origin and evolution of mitochondrial inner membrane composition
In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.
Resolution in super-resolution microscopy
Super-resolution microscopy (SRM) has emerged as a powerful tool for biological discovery. In this Perspective, Kirti Prakash and colleagues compile expert opinions on crucial, yet often overlooked, aspects of SRM that are essential for maximising its benefits and advancing the field.
