Issues
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Cover image
Cover Image
Cover: Mitotic MCF10A cells were imaged by confocal microscopy. One side of the mirrored layout shows the distribution of Scribble (cyan) and E-cadherin (magenta) from mitotic cortex to the extension of retraction fibres, and the opposite side shows F-actin (black). See article by A. S. Chann et al. (jcs260547).
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RESEARCH HIGHLIGHTS
EDITORIAL
CELL SCIENTISTS TO WATCH
REVIEWS
Complexity and self-organization in the evolution of cell polarization
Summary: We review the evolution of self-organizing systems, focusing on cell polarization in Saccharomyces cerevisiae and its relatives, and offer a shift in perspective on evolution at the molecular scale.
Three's a crowd – why did three N-terminal methyltransferases evolve for one job?
Summary: A discussion of the catalytic and non-catalytic functions of the three N-terminal methyltransferases to enable better understanding of their biological roles.
RESEARCH ARTICLES
Matrix stiffness regulates Notch signaling activity in endothelial cells
Highlighted Article: Substrate stiffness modulates mechanotransduction of Notch signaling in endothelial cells. This might have implications for pathologies involving extracellular matrix stiffening, such as tumor growth.
AMG232 inhibits angiogenesis in glioma through the p53–RBM4–VEGFR2 pathway
Summary: AMG232 inhibits glioma angiogenesis via the p53–RBM4–VEGFR2 pathway, which might provide a potential target and an alternative strategy for combined glioma therapy.
A member of the claudin superfamily influences formation of the front domain in pheromone-responding yeast cells
Summary: The claudin superfamily member, Dcv1, facilitates the proper localization of plasma membrane lipids and proteins that are required for front–rear polarity, efficient chemotropism and cell fusion in yeast.
CCDC86 is a novel Ki-67-interacting protein important for cell division
Highlighted Article: CCDC86 was identified as a novel component of the perichromosomal layer and was found to be important for chromosome segregation. It represents a strong prognostic marker for neuroblastoma patients.
Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity
Highlighted Article: A unique genetic coordination between the TIM22 complex and YME1 machinery balances mitochondrial protein biogenesis and quality control, thereby maintaining cellular health.
SART3 associates with a post-splicing complex
Highlighted Article: SART3 interacts with post-splicing complexes in a DHX15-dependent manner, suggesting that SART3 associates with the post-splicing complex, interacts there with U6 snRNA and initiates its recycling.
Cardiomyocyte differentiation from human induced pluripotent stem cells is delayed following knockout of Bcl-2
Summary: Bcl-2 regulates the temporal trajectory of human induced pluripotent stem cell differentiation towards cardiomyocytes in a c-Myc dependent manner.
Reorganization of the DNA replication landscape during adipogenesis is closely linked with adipogenic gene expression
Summary: Regulation of the temporal order of DNA replication during differentiation of 3T3-L1 cells into adipocytes was uncovered and found to be linked with adipogenesis potential.
Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding
Summary: Two members of the PDI family, ERp57 and ERdj5, assist secretory protein folding by correcting non-native disulfide bonds. Their contrasting dependency on a reducing pathway reflects their different roles as isomerase and reductase.
The mitotic role of adenomatous polyposis coli requires its bilateral interaction with tubulin and microtubules
Summary: The C-terminal domain of adenomatous polyposis coli (APC) regulates microtubule dynamics and organises ring-like tubulin oligomers around the microtubule wall, and plays a role in mitotic spindle function.
Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms
Summary: E-cadherin and Scribble dynamically relocate during division of single cells to orient the mitotic spindle and control placement of the daughter cells.
Endosomal vesicle fusion machinery is involved with the contractile vacuole in Dictyostelium discoideum
Summary: Transcriptomics and fluorescence microscopy of the amoeba Dictyostelium show the involvement of Rabs and SNAREs in regulation of the contractile vacuole, and phylogenetics addresses its evolutionary origins.
The fission yeast kinetochore complex Mhf1–Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation
Summary: Mhf2, a component of the inner layer of the proteinaceous kinetochore supercomplex, regulates the spindle assembly checkpoint and faithful chromosome segregation.
FIRST PERSON
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The deadline for abstract submission and early-bird registration is 17 January 2025.
Fantastic proteins and where to find them – histones, in the nucleus and beyond
In this Review, Johanna Grinat and colleagues provide an evolutionary perspective of histones, nuclear chromatin and extracellular chromatin biology, describing the known extranuclear and extracellular functions of histones.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
How to reduce your lab's carbon footprint
All stakeholders – from those working in the lab to those providing funding and infrastructure – have an important role to play to becoming more sustainable. In this Essay, Julie Welburn discusses what lab users can collectively do to transform biomedical research into a discipline that is significantly and positively sustainable.
