Skip to Main Content

Advertisement

Skip Nav Destination

Issues

RESEARCH HIGHLIGHTS

EDITORIAL

CELL SCIENTISTS TO WATCH

REVIEW

Summary: We review the evolution of self-organizing systems, focusing on cell polarization in Saccharomyces cerevisiae and its relatives, and offer a shift in perspective on evolution at the molecular scale.

Summary: A discussion of the catalytic and non-catalytic functions of the three N-terminal methyltransferases to enable better understanding of their biological roles.

RESEARCH ARTICLES

REVIEW COMMONS TRANSFER

Highlighted Article: Substrate stiffness modulates mechanotransduction of Notch signaling in endothelial cells. This might have implications for pathologies involving extracellular matrix stiffening, such as tumor growth.

Summary: AMG232 inhibits glioma angiogenesis via the p53–RBM4–VEGFR2 pathway, which might provide a potential target and an alternative strategy for combined glioma therapy.

Summary: The claudin superfamily member, Dcv1, facilitates the proper localization of plasma membrane lipids and proteins that are required for front–rear polarity, efficient chemotropism and cell fusion in yeast.

Summary: CCDC86 was identified as a novel component of the perichromosomal layer and was found to be important for chromosome segregation. It represents a strong prognostic marker for neuroblastoma patients.

Summary: A unique genetic coordination between the TIM22 complex and YME1 machinery balances mitochondrial protein biogenesis and quality control, thereby maintaining cellular health.

Summary: SART3 interacts with post-splicing complexes in a DHX15-dependent manner, suggesting that SART3 associates with the post-splicing complex, interacts there with U6 snRNA and initiates its recycling.

Summary: Bcl-2 regulates the temporal trajectory of human induced pluripotent stem cell differentiation towards cardiomyocytes in a c-Myc dependent manner.

Summary: Regulation of the temporal order of DNA replication during differentiation of 3T3-L1 cells into adipocytes was uncovered and found to be linked with adipogenesis potential.

Summary: Two members of the PDI family, ERp57 and ERdj5, assist secretory protein folding by correcting non-native disulfide bonds. Their contrasting dependency on a reducing pathway reflects their different roles as isomerase and reductase.

Summary: The C-terminal domain of adenomatous polyposis coli (APC) regulates microtubule dynamics and organises ring-like tubulin oligomers around the microtubule wall, and plays a role in mitotic spindle function.

Summary: E-cadherin and Scribble dynamically relocate during division of single cells to orient the mitotic spindle and control placement of the daughter cells.

Summary: Transcriptomics and fluorescence microscopy of the amoeba Dictyostelium show the involvement of Rabs and SNAREs in regulation of the contractile vacuole, and phylogenetics addresses its evolutionary origins.

Summary: Mhf2, a component of the inner layer of the proteinaceous kinetochore supercomplex, regulates the spindle assembly checkpoint and faithful chromosome segregation.

FIRST PERSON

Close Modal

or Create an Account

Close Modal
Close Modal