Issues

Summary: This Review discusses how septins interact with biomimetic membranes, with a focus on septin organization, curvature sensitivity and the resulting membrane deformations.

Summary: Organ-on-chip culture models are emerging in vitro experimental systems for biological discovery in the context of tissue morphogenesis.

Summary: Rac plays a major role in the initial transcriptional response to extracellular matrix stiffness and mediates the stiffness-dependent repression of ATF3, resulting in the induction of cyclin D1.

Summary: SARS-CoV-2 non-structural protein 2 (NSP2) enhances the translational repression of host microRNA target mRNAs through interaction with GIGYF2 that forms a complex with the miRNA-induced silencing complex.

Highlighted Article: DAXX plays an essential role in ESCs, organizing the 3D heterochromatin structure. This maintenance ensures transcriptional repression of silent regions through targeted chromatin modifications.

Summary: A complex regulatory circuitry, in which Pten is a central player, underlies the laminin-rich ECM-induced cell cycle arrest that is crucial for mammary gland development, architecture and function.

Summary: Low ATG4B expression in pancreatic ductal adenocarcinoma is associated with poor clinical outcomes, and combined loss of ATG4B and ATG4A results in cell cycle defects, with implications for therapeutic strategies.

Highlighted Article: In Drosophila, age-related decreased kidney function is due to loss of epithelial barrier integrity and failure of fluid homeostasis, effects phenocopied by cell-specific knockdown of the essential junctional protein Snakeskin.

Summary: Appropriate levels of the inner nuclear membrane protein Bqt4 are maintained by ubiquitin–proteasome-mediated degradation. Aberrant accumulation of Bqt4 disturbs nuclear membrane homeostasis.

Summary: We present a light-activated proximity labeling technology for mapping protein–protein interactions at the cell membrane with high accuracy and precision.