Issues
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Cover image
Cover Image
Cover: Myelination in a compartmentalised murine Schwann cell–dorsal root ganglion neuron coculture in microfluidic chambers. Periaxin-labelled myelin segments (green) cover neurofilament light chain-labelled axons (magenta), and nuclei are labelled with DAPI (blue). This method of coculture allows separate genetic manipulation of Schwann cells and neurons, use of cells from different transgenic animals, axotomies to study injury, and drug treatments in a purely murine culture with robust myelination. Schwann cells protect axons after injury and delay axon degeneration in these cocultures, irrespective of whether they are myelinating or not. See article by C. Mutschler et al. (jcs261557).
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RESEARCH HIGHLIGHTS
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Chloroplast protein translocation pathways and ubiquitin-dependent regulation at a glance
Summary: The development and operation of chloroplasts depends on the correct targeting, translocation, assembly and degradation of thousands of different chloroplast proteins. An overview of these diverse proteostatic processes is presented.
REVIEW
Response of cells and tissues to shear stress
Summary: We discuss shear stress in response to fluid dynamics and invite the reader to study shear stress in biological systems, in which shear stress emerges from cell and tissue interactions.
SHORT REPORT
Live-imaging studies reveal how microclots and the associated inflammatory response enhance cancer cell extravasation
Highlighted Article: Live imaging in zebrafish larvae reveals that fibrin and platelets in the pre-metastatic niche can recruit pro-metastatic innate immune cells and drive cancer metastasis.
RESEARCH ARTICLES
Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells
Highlighted Article: Paxillin is shown to be a key molecule important in the function of fibrosis effector cells, which emphasizes a novel role for it in liver fibrosis and cirrhosis, a leading cause of morbidity and mortality worldwide.
Surf4 collaborates with derlin-2 and derlin-1 to mediate cyclooxygenase-2 translocation to the cytosol for degradation
Highlighted Article: An endoplasmic reticulum-associated degradation pathway mediated by derlin-2, derlin-1, Surf4 and caveolin-1 facilitates cyclooxygenase-2 translocation and degradation.
Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium
Summary: LPS triggers a SOCS3-dependent epigenetic and transcriptional coordinated response in the kidney endothelium. Experiments in cultured endothelial cells show that this response depends at least in part on IL-6-induced STAT3 and JunB activity.
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN
Summary: Following CHIP-mediated monoubiquitylation, PTEN undergoes nuclear import, which is aided by KPNA1 and enhanced by oxidative stress. PTEN monoubiquitylation also increases its interaction with nuclear CHIP.
ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer
Summary: ILT4 is identified as an unfavorable prognostic biomarker as well as a novel driver for triple-negative breast cancer (TNBC) progression, suggesting that targeting ILT4 could be a strategy to combat TNBC.
TOOLS AND RESOURCES
Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell–neuron cocultures
Highlighted Article: A novel method for compartmentalised mouse myelinating Schwann cell–DRG neuron cocultures, showing that Schwann cell myelination status does not influence their axon protective effect after injury.
FIRST PERSON
PUBLISHER’S NOTE
CORRECTION
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis

In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.