Issues

Summary: We provide a snapshot of the current understanding of the biology and pathological roles of leucine-rich repeat kinase 2.

Summary: In this Review, we discuss recent advances in our understanding of the cellular biochemistry of mitochondrial phospholipids and provide an overview of rare human genetic disorders of mitochondrial phospholipid metabolism.

Summary: Zika virus (ZIKV) poses an increasing threat to human health. We provide evidence to support a positive correlation between host cell contractility and ZIKV infection efficacy.

Summary: Y-27632 conditionally reprograms epidermal stem cells not only by inhibiting Rho kinases but also via an unidentified mechanism, contrary to the presumption that Rho kinase inhibition alone renews epidermal stem cells.

Summary: The level of p53 amyloid, whether wild-type or mutant, is highly correlated with oral and stomach cancer grades. p53 amyloid can aggregate p63 and p73 in a grade-dependent manner.

Highlighted Article: Motility is essential for apicomplexan parasites to infect their hosts. The spirally arranged cortical microtubules underlie the helicity of movement of the human parasite Toxoplasma gondii.

Summary: The clathrin adaptors Ent3p, Ent5p and AP-1 regulate Vps9p localization to Vps21p compartments and are recruited to the trans-Golgi network by GGA adaptors, yeast Rab11s and phosphatidylinositol-4-phosphate.

Highlighted Article: Salinomycin impairs the morphology and function of the Golgi and blocks proper post-translational modification and sorting of proteins, to which EMT cells are particularly susceptible.

Summary: Matrisome AnalyzeR is a suite of tools, including a web-based app and an R package, designed to facilitate the annotation and quantification of extracellular matrix components in big datasets.