Issues

Summary: We compare processes involved in transport of folded proteins across membranes, with an emphasis on protein import into peroxisomes, and discuss different peroxisomal protein quality control pathways.

Summary: A review of how hemidesmosomes are emerging as playing a crucial role in tissue maintenance, healthy aging and mechanotransduction across different organisms.

Highlighted Article: Primary vascular endothelial cells internalise albumin by macropinocytosis, and albumin is then recycled from maturing macropinosomes by an FcRn-mediated process.

Summary: UMAD1 is identified as a novel component of the ESCRT machinery, and specifically facilitates cytokinetic abscission. UMAD1 plays an unexpected role in the dynamic exchange of membrane remodelling complexes at the midbody.

Summary: ARF6 is a key factor in targeting palmitoylated proteins from the Golgi to the plasma membrane, and its activity depends on its N-terminal myristoylation and GTP-bound form.

Summary: TGF-β induces SRC expression at the transcriptional level by activating an intragenic SRC enhancer. TGF-β-induced SRC upregulation then promotes cancer cell invasion and metastasis in a subset of human malignancies.

Summary: By utilizing proximity labeling of proteins in the lipid raft domains of the plasma membrane, this work reveals the molecular environment and dynamics triggered by the B cell receptor upon antigen activation.

Summary: The PI(4,5)P₂-binding domain tubbyCT is recruited into ER–PM junctions through coincidence detection of PI(4,5)P₂ and extended synaptotagmin 3 (E-Syt3).

Highlighted Article: The study reveals that C17orf80 is a novel human mitochondrial nucleoid-associated protein that interacts with the IMM and enriches in nucleoids under chemically induced mtDNA replication stress.

Highlighted Article: We developed a correlative light and electron microscopy workflow to target environmental microorganisms from heterogeneous samples and, as proof of principle, revealed the 3D ultrastructure of a marine dinoflagellate.

Summary: We show that ZnUMBA can measure barrier repair dynamics after laser injury in Xenopus embryos and can detect tight junction leakage in zebrafish embryos and cultured mammalian epithelial cells.