Issues

Summary: Most proteins are acetylated at the N terminus. Here, we discuss how N-terminal acetyl groups influence protein functions and cellular processes important for human health.

Summary: We review theoretical works, demonstrating that curved membrane-bound protein complexes that recruit the protrusive forces of the cytoskeleton self-organize the cytoskeleton and the membrane to form lamellipodia.

Highlighted Article: Cancer-associated fibroblasts impart a migratory advantage onto already highly invasive breast cancer cell spheroids owing, in part, to mitochondrial transfer via tunneling nanotubes and the associated bioenergetic rewiring.

Highlighted Article: This study expands upon the role of Dictyostelium PIPkinA, furthering our understanding of the underlying mechanism of chemorepulsion and informing development of therapeutics for acute respiratory distress syndrome.

Summary: PSEN, Endo16, Wnt5, Hnf6 and Gsc are transcribed in both the sense and antisense directions in the sea urchin. A general control of the sense-antisense transcription could be crucial for correct embryonic development.

Summary: Activation of spleen tyrosine kinase by Src- and Abl-family kinases is required for maximal Leishmania uptake by macrophages and disease in a mouse model of cutaneous leishmaniasis.

Summary: Sphingolipid depletion triggers plasma membrane remodeling by altering endocytosis of amino acid transporters.

Highlighted Article: The Nir2 and Nir3 lipid transfer proteins maintain phosphoinositide signaling and actin dynamics, supporting effective phagocytosis.

Summary: Glc7-mediated dephosphorylation of the yeast BAR domain protein Pil1 modulates plasma membrane subdomains to promote transporter retention and recovery potential.

Summary: When exposed to harmful environmental conditions, cells trigger stress granule formation to reprioritize stress responsive genes (p53 mRNA) by sequestering its negative regulator hCdc73.

Summary: Rab29 phosphorylation at Ser185 occurs under lysosomal stress and is mediated by PKCα and PKCδ; this phosphorylation regulates lysosome morphology and Rab29 localization to lysosomes together with LRRK2.

Summary: Cisplatin causes persistent and aberrant stress granule formation which might contribute to its ototoxicity, a common side effect of chemotherapy treatment for cancer.