Issues

Summary: An overview of the different insertases and translocases that integrate proteins into cellular membranes.

Summary: We review recent advances revealing how diverse viruses exploit host endoplasmic reticulum membrane chaperones and morphogenic machinery to cause infection.

Summary: At the end of cell division, cells can delay final separation and instead remain connected. Here, we discuss how and why this occurs in normal development and disease.

Summary: MTP18 interacts with LC3 to activate mitophagy through Parkin-dependent outer mitochondrial membrane rupture to eliminate dysfunctional mitochondria and protect oral cancer cells.

Summary: Myosin II accumulation along the boundary between differently fated cells is not necessary to drive elimination and sorting of harmful cells in Drosophila larval wing discs.

Highlighted Article: GTAP-1 and GTAP-2, two unconventional components of the γ-tubulin complex in C. elegans, contribute to targeting of the γ-tubulin complex to embryonic centrosomes and germ cell membranes in adults.

Summary: An aggregation-prone variant of Tau affects mitochondrial structure, correlates with reduced neuronal complexity, and invokes a rescue mechanism involving intercellular mitochondrial transport.

Summary: iRhom2 and ADAM17 control EGF receptor signaling. Gain-of-function mutations in the cytoplasmic domain of iRhom2 affect the function of ADAM17 in cells and during mouse development.

Summary: Single cells captured from a highly heterogeneous triple-negative breast cancer cell population exhibit higher migration speed and focal adhesion dynamics, which are retained by their progeny as a result of a motility-related transcriptomic profile.

Summary: Independent triggers of release (Ca²⁺ and cAMP) induce different levels of fusion pore dilation to vary the composition of proteins released from synaptic dense-core vesicles.

Highlighted Article: Membrane contact sites established by tethering proteins allow communication among organelles. Tethering proteins can influence the recruitment and mobility of other tethers of the same interface.

Summary: A genetic loss-of-function study in mice reveals that the splicing factor Quaking (QKI) is a crucial regulator of circular RNA formation in the heart.

Summary: Myofibrils in muscles are very regular structures. We show that the scaffolding protein Zasp52 recruits the oxoglutarate dehydrogenase complex to coordinate myofibril growth and maintain their regularity.