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RESEARCH HIGHLIGHTS

CELL SCIENCE AT A GLANCE

Summary: We highlight the major tactics employed by viruses to evade or antagonize cellular machineries and pathways that sense viral nucleic acid and elicit antiviral interferon responses.

REVIEW

Summary: We review the function of p300/CBP in autophagy, its regulation by cellular pathways and small molecules, and the role of p300/CBP-regulated autophagy in human disorders.

RESEARCH ARTICLES

Summary: The fission yeast polycystin Pkd2 promotes cell proliferation. We discovered that the cytoplasmic tail of this essential ion channel promotes its intracellular trafficking and prevents its clustering in the plasma membrane.

Summary: The HAUS complex is a direct target of the Ran-GTP pathway, suggesting that branching microtubule nucleation is directly regulated by the Ran-GTP gradient around chromosomes in dividing cells.

Highlighted Article: Knockout mouse studies of SCG10, a regulator of microtubule dynamics in neurons, highlight the importance of SCG10-mediated microtubule dynamics for peripheral axon maintenance and regeneration.

Highlighted Article: Ivy1 interacts with Rab7-like protein Ypt7 and PI(3)P, and is a novel substrate of the vacuolar casein kinase Yck3. Ivy1 phosphorylation determines its localization and function at endosomes and vacuoles.

Summary: Simulations of axonal transport in C. elegans neurons suggest that long-lived stationary vesicle clusters modulate net cargo flow, and that vesicle reversals regulate the proportion of stationary clusters and moving vesicles.

Summary: A distinct gene regulatory mechanism exists in which histone acetyltransferases KAT2A and KAT2B drive divergent functions of self-renewal and differentiation in human keratinocytes, with implications for cutaneous wound healing.

Summary: Optogenetically driven Ca2+ oscillation promotes mitochondrial fission by increasing phosphorylation at Ser616 of DRP1 via the activation of CaMKII, ERK and CDK1.

Summary: EPLIN-β is degraded by ornithine decarboxylase antizyme 1 (Az1) in a proteasome-mediated, ubiquitination-independent manner. Az1 absence leads to elevated EPLIN-β levels, causing enhanced cellular migration.

Summary: Vinculin Y822 modulates ligand binding to control focal adhesion morphology and tumorigenicity in cancer cells.

TOOLS AND RESOURCES

REVIEW COMMONS TRANSFER

Summary: By using genetically encoded unnatural amino acids and click chemistry, we developed minimally invasive tags for live-cell labeling of large neuronal transmembrane proteins and ion channels.

REVIEW COMMONS TRANSFER

Highlighted Article: Endocytic recycling pathways control cellular processes including cell migration. Here, we identify protein cargoes and trafficking machinery associated with the major recycling regulators Rab4a, Rab11a and Rab25.

Summary: Tumor suppressor protein p53 is one of the hub factors of the cellular stress responses. Our novel reporter system allows easy and precise visualization of the transcriptional activity of endogenous p53.

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