Issues

Summary: Peroxisomes form membrane contact sites with many other cell organelles. In this Review, an overview is given of the current knowledge on peroxisomal membrane contact sites in yeast.

Summary: Mitophagy contributes to the maintenance of nervous system homeostasis. Defective or dysregulated mitophagy has been implicated in the pathogenesis of neurodegenerative diseases.

Highlighted Article: Using heterogenous neutrophils mobilized following endotoxin administration in humans, we show that neutrophils with nuclei segmented into more lobes can migrate faster in a physically confined space.

Summary: We show, through biochemical reconstitution experiments and live-cell imaging, that functions and localization of Kar3 are dictated by the stage of the cell cycle and the activities of two Kar3 accessory binding partners – Cik1 and Vik1.

Highlighted Article: The Y-complex nucleoporins Nup133 and Seh1 have roles in gene regulation upon neuroectodermal differentiation, and this process can be uncoupled from nuclear pore basket integrity.

Highlighted Article: The human octameric septin complex forms a two-layered mesh of orthogonal filaments on the membrane, which is sensitive to micrometric membrane curvature and drives membrane reshaping.

Summary: NSD3-dependent methylation contributes to sister chromatid cohesion by ensuring proper kollerin recruitment and subsequent cohesin loading during mitotic exit.

Summary: Discs large protein 1 (Dlg1) interacts with the gap junction protein connexin 43 (Cx43) in keratinocytes. Dlg1 depletion leads to low Cx43 levels and reduced intercellular communication. Dlg1 might maintain Cx43 at the plasma membrane.

Summary: Lack of the Cbf11 transcription factor in S. pombe disrupts lipid metabolism, leading to mitotic defects involving aberrant cohesin dynamics and chromatin structure.

Summary: Fibroblasts from aged mice show chromosomal instability. Oxidative stress causes replication stress, which promotes chromosomal instability.

Summary: Radial spoke head protein 9 (RSP9) is found in the flagella of trypanosomatids and malaria parasites, and is important for motility in trypanosomatids but critical for fertilisation in Plasmodium.

Summary: CYRI-B limits CEACAM3-mediated phagocytosis.

Summary: Chromosome losses and gains are most prominent in solid tumors. Use of novel chromosome reporters shows that confinement of normal and cancer cells drives chromosome losses, which myosin-II suppression maximizes.