Cover: Tubular network of primary human endothelial cells cultured on a bed of primary human fibroblasts in the presence of VEGF-A. Endothelial cells are labelled for PECAM-1 (red), and endothelial and fibroblast nuclei (blue). See article by W. R. Critchley et al. (jcs260657).
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CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Aggrephagy at a glance
Summary: A discussion of the molecular mechanisms of the removal of protein aggregates by the selective autophagy pathway termed aggrephagy. We describe its regulation, focusing on neuronal cells, and potential therapeutic manipulation.
Regulation of autophagy gene expression and its implications in cancer
Summary: Autophagy is an essential process that is implicated in several diseases. We discuss recent findings that uncover regulators of autophagy in mammalian cells with a focus on cancer.
Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition
Highlighted Article: Single-cell intracellular pH (pHi) measurements reveal oscillations during the mammalian cell cycle. Manipulating pHi alters phase lengths and transitions, suggesting pHi dynamics regulate the cell cycle.
Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells
Summary: The BAR domain protein pacsin 2 plays an essential role in collective cell migration of cancer cells by regulating internalization of N-cadherin.
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability
Summary: The histone H3/H4 chaperone CHAF1B prevents mislocalization of CENP-A to non-centromeric regions, thus preventing chromosomal instability.
Clues on the dynamics of DNA replication in Giardia lamblia
Summary: Single-molecule analysis of DNA replication in Giardia lamblia.
CDK actively contributes to establishment of the stationary phase state in fission yeast
Summary: Upon glucose exhaustion, yeast cells exit the cell cycle and enter stationary phase through CDK inhibition. However, we show that CDK actively contributes to the stationary phase establishment.
GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region
Highlighted Article: GIPC3 couples the molecular motors MYO6 and MYO18A to actin cytoskeleton structures in hair cells. GIPC3 is necessary for shaping cuticular plate of the hair cell and hence the arrangement of the stereocilia in the hair bundle.
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function
Summary: The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 modulate the levels of VEGFR2, which regulates endothelial function and angiogenesis.
Coupled protein quality control during nonsense-mediated mRNA decay
Summary: Nonsense-mediated mRNA decay utilizes a coupled protein quality control pathway to coordinate degradation of both the aberrant mRNA and its associated nascent polypeptide chain.
The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria
Summary: The conserved yeast mitochondrial inner membrane protein Cqd1 interacts with the outer membrane proteins Por1 and Om14. Additionally, Cqd1 is important for maintaining mitochondrial homeostasis.
Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation
Summary: The ceramide synthase homolog Tlc4 suppresses cell lethality associated with an aberrant nuclear membrane. Translocation of Tlc4 from the endoplasmic reticulum to the Golgi is linked to its suppressive activity.
TOOLS AND RESOURCES
Cell-based optimization and characterization of genetically encoded location-based biosensors for Cdc42 or Rac activity
Highlighted Article: A systematic, cell-based comparison of G-protein-binding domains for their potential as localization-based, genetically encoded biosensors for imaging of Cdc42 or Rac activity in single cells.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Call for papers: Cell and Tissue Polarity
We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Journal of Cell Science a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
FocalPlane Image Competition 2023
FocalPlane’s 2023 image competition is underway, in celebration of the community site’s third birthday. Click here for submission details and information on how to showcase your favourite image.