Issues
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Cover image
Cover Image
Cover: Tubular network of primary human endothelial cells cultured on a bed of primary human fibroblasts in the presence of VEGF-A. Endothelial cells are labelled for PECAM-1 (red), and endothelial and fibroblast nuclei (blue). See article by W. R. Critchley et al. (jcs260657).
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RESEARCH HIGHLIGHTS
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Aggrephagy at a glance
Summary: A discussion of the molecular mechanisms of the removal of protein aggregates by the selective autophagy pathway termed aggrephagy. We describe its regulation, focusing on neuronal cells, and potential therapeutic manipulation.
REVIEW
Regulation of autophagy gene expression and its implications in cancer
Summary: Autophagy is an essential process that is implicated in several diseases. We discuss recent findings that uncover regulators of autophagy in mammalian cells with a focus on cancer.
RESEARCH ARTICLES
Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition
Highlighted Article: Single-cell intracellular pH (pHi) measurements reveal oscillations during the mammalian cell cycle. Manipulating pHi alters phase lengths and transitions, suggesting pHi dynamics regulate the cell cycle.
Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells
Summary: The BAR domain protein pacsin 2 plays an essential role in collective cell migration of cancer cells by regulating internalization of N-cadherin.
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability
Summary: The histone H3/H4 chaperone CHAF1B prevents mislocalization of CENP-A to non-centromeric regions, thus preventing chromosomal instability.
Clues on the dynamics of DNA replication in Giardia lamblia
Summary: Single-molecule analysis of DNA replication in Giardia lamblia.
CDK actively contributes to establishment of the stationary phase state in fission yeast
Summary: Upon glucose exhaustion, yeast cells exit the cell cycle and enter stationary phase through CDK inhibition. However, we show that CDK actively contributes to the stationary phase establishment.
GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region
Highlighted Article: GIPC3 couples the molecular motors MYO6 and MYO18A to actin cytoskeleton structures in hair cells. GIPC3 is necessary for shaping cuticular plate of the hair cell and hence the arrangement of the stereocilia in the hair bundle.
The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function
Summary: The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 modulate the levels of VEGFR2, which regulates endothelial function and angiogenesis.
Coupled protein quality control during nonsense-mediated mRNA decay
Summary: Nonsense-mediated mRNA decay utilizes a coupled protein quality control pathway to coordinate degradation of both the aberrant mRNA and its associated nascent polypeptide chain.
The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria
Summary: The conserved yeast mitochondrial inner membrane protein Cqd1 interacts with the outer membrane proteins Por1 and Om14. Additionally, Cqd1 is important for maintaining mitochondrial homeostasis.
Ceramide synthase homolog Tlc4 maintains nuclear envelope integrity via its Golgi translocation
Summary: The ceramide synthase homolog Tlc4 suppresses cell lethality associated with an aberrant nuclear membrane. Translocation of Tlc4 from the endoplasmic reticulum to the Golgi is linked to its suppressive activity.
TOOLS AND RESOURCES
Cell-based optimization and characterization of genetically encoded location-based biosensors for Cdc42 or Rac activity
Highlighted Article: A systematic, cell-based comparison of G-protein-binding domains for their potential as localization-based, genetically encoded biosensors for imaging of Cdc42 or Rac activity in single cells.
FIRST PERSON
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
Diversity of microtubule arrays in animal cells at a glance
In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
