Issues

Summary: A summary of the mechanisms employed by the three eukaryotic RNA polymerases to cease transcription, which have more commonalities than previously appreciated.

Summary: This Review elaborates the functions of cytoskeletal vimentin during bacterial infection and host defense, and reciprocally provides an overview of the impact of bacterial infection on the fate of vimentin.

Highlighted Article: Bifurcation of mammary tubes is accomplished through spatiotemporal regulation of luminal epithelial cell migration and is regulated by TGF-β signaling.

Summary: Microtubules and mitochondria cooperate to ensure that a fission yeast cell divides symmetrically and that mitochondria are divided properly between the resulting daughter cells.

Summary: Mammalian cells form nuclear buds and micronuclei containing autophagy proteins in a basal way and in response to DNA double strand breaks, suggesting homeostatic nuclear maintenance by nucleophagy.

Highlighted Article: Bodies containing 53BP1, RIF1 and lamin A/C residing adjacent to a subset of centromeres in mitotically arrested cancer cells regulate 53BP1 to facilitate cell division following a problematic mitosis.

Highlighted Article: The mains driver of ERK activity heterogeneity occurs during the cell cycle of sister cells leading to heterogeneity in intermitotic time.

Summary: The transcriptional co-regulator CITED1 functions as a modulator of the macrophage interferon-γ response and is itself an interferon-γ-responsive gene.

Summary: Inhibition of mitochondrial respiration decreases the proliferation of yeast cells that are mutant for Cdc28 (the homolog of mammalian Cdk1) by reducing Cdc28 stability through the Hsp90 co-chaperone Cdc37.

Summary: STAT3 represents an attractive yet complex pharmacological target for diseases with aberrant angiogenesis as its effects are strongly dependent on its phosphorylation status and simultaneous activity of other intracellular signaling pathways.

Summary: We establish a protocol that allows STED imaging of Plasmodium spp. upon clearing of parasites with CUBIC-P, which dissolves hemozoin crystals.

Summary: Prog-Plot is a visual and objective tool for specifying regression models for false discovery rate correction.