Issues

Summary: The study of how neighboring tissues physically interact with each other, inter-tissue adhesion, is an emerging field at the interface of cell biology, biophysics and developmental biology.

Summary: The microtubule cytoskeleton underlies diverse biological processes. Microtubules themselves are composed of multiple tubulin isotypes. We review how model organisms are revealing how these isotypes mediate distinct cellular functions.

Summary: Ca²⁺ and the conventional calpains 1 and 2 regulate microtubule detyrosination. They could indirectly influence vasohibin activity or possibly control another still unknown tubulin carboxypeptidase.

Summary: Major histocompatibility complex class I heavy chains form noncovalent dimers at the cell surface that are shown to be dynamic and short-lived.

Highlighted Article: Exogenous stimulation with electric currents enables DNA damage repair and stem cell reconstitution in planarian tissues exposed to a lethal dose of ionizing radiation.

Highlighted Article: The GID ubiquitin ligase complex localizes to primary cilia, influences sonic hedgehog signaling and causes phenotypes reminescent of ciliopathies.

Highlighted Article: Mitochondrial antiviral-signalling protein (MAVS) is a favoured client of the cytosolic BAG6 complex. We discuss how this dynamic interaction may modulate MAVS biogenesis at signalling membranes.

Summary: The fragile X mental retardation protein protects the epithelial lining of the respiratory tract from xenobiotic stresses by facilitating the induction of the integrated stress response pathway.

Summary: In contrast to PEX16-deficient fibroblasts from Zellweger syndrome patients, PEX16-knockout HeLa, HEK293 and CHO-K1 cell lines established using the CRISPR/Cas9 system can partially maintain peroxisomes.

Summary: Highly localized TPC1-mediated Ca²⁺ release from endolysosomes contributes to the capture and attachment of superficial slow skeletal muscle cells at myoseptal junctions in zebrafish.

Highlighted Article:Dictyostelium PkcA controls stationary phase entry by negatively regulating polyphosphate concentration and F-actin polymerization under high shear stress, in turn governing pinocytosis and exocytosis.

Summary: The Anx2–Ahnak complex is a novel mitotic cortical element transmitting adhesion cues to regulate cortical NuMA–dynein distribution and mitotic spindle orientation in human cells.