Issues

Summary: Proteasomes are large multisubunit complexes responsible for destroying proteins. This Review discusses how new proteasomes are assembled.

Summary: A multiscale review on leaf morphogenesis, focusing on coordinated, non-cell-autonomous growth regulations via metabolism and biomechanics.

Summary: In mechanically constrictive microenvironments, amoeboid migrating melanoma cells require emerin for the precise calibration of nuclear stiffness.

Highlighted Article: The yeast LYST homolog Bph1 is an endosomal Rab5 effector that maintains endosomal function. Loss of Bph1 causes defects in endoytosis and Atg8 lipidation at endosomes, suggesting a function in endosomal biogenesis.

Summary: Senescence onset after G2 arrest requires Chk1 downregulation and inhibition of CycD1–CDK RB kinases by p21 and is compromised in cancer cells due to delayed p21 induction and sustained Chk1 activity.

Summary: ATAC-seq and footprinting analysis reveals the transcription factor networks underlying NODAL/Activin signalling responses and a self-enabling regulatory mechanism that explains the expression of delayed NODAL/Activin target genes.

Highlighted Article: During centriole maturation, the concomitant mitotic removal of centrobin and the recruitment of distal appendage proteins in human cells are both independent, yet both depend on the kinase PLK1.

Summary: The catalytic activity of the deacetylase Sirtuin 7 is inhibited in vitro and in vivo by the naphthoquinones menadione and plumbagin in a manner dependent on sulfhydryl arylation reactions.

Summary: Mitochondria genome-encoded miRNAs (mitomiRs) physically interact with the RISC protein Ago2 inside mitochondria and cytoplasm to regulate mitochondrial DNA copy number in breast cancer.

Summary: Mitotic PCM scaffold assembly in C. elegans embryos requires sequential domain interactions of SPD-5 mediated by PLK-1 phosphorylation.

Summary: The Braf V600E mutation transforms mouse late PGCs of both sexes in teratocarcinomas expressing stemness markers Sox2, Oct4 and Prdm14. Braf V600E ovaries show high numbers of growing and multi-ovular follicles and contain metaphase I oocytes.

Summary: We identified a point mutation in human coilin clone deposited in Addgene that prevents Cajal body formation in mouse and human coilin-knockout cells and negatively affects the integrity of Cajal bodies in wild-type cells.