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Special Issue: Cell Biology of Lipids




Summary: Perilipins coat lipid droplets to regulate their metabolism and signaling, influencing disease development.

Summary: This Cell Science at a Glance article and accompanying poster provides an overview of the cellular mechanisms governing lipophagy in yeast and mammals.


Summary: We discuss emerging roles of VPS13-family proteins in vesicle-independent bulk lipid transport between organelles, the possible functions of such transport and the underlying molecular mechanisms.


Summary: Lipid droplets in the nucleus form through pathways that are different from those of their cytoplasmic counterparts and appear to have unique functions, but many questions remain to be addressed, as reviewed here.

Summary: Coherent Raman scattering microscopy offers label-free imaging of lipid droplets with chemical specificity. Here, we discuss the recent advancement in the field.


Summary: Transport of lipids across vessel walls is vital for tissue function. We show that adipocytes regulate this process by paracrine secretion of lactate, linking carbohydrate metabolism to control of fat influx.

Summary: Dynamic S-acylation of Ca2+ release-activated channel Orai1 is required for its recruitment to the plasma membrane subdomains and subsequent activation.


Summary: CFTR clustering in ceramide-rich platforms is independent of protein–protein interactions, driven by lipid phase separation, prevented by CFTR mutations that cause misfolding and restored by Trikafta correctors.

Summary: ADAR1 acts as an inhibitor of adipogenesis via enhanced production of miR-155-5p and downregulating the adipogenic early transcription factor C/EBPα.

Summary: Changing neutral sphingomyelinase 2 activity regulates small extracellular vesicle secretion through modulation of V-ATPase activity.

Summary: An increase in DHA-containing phospholipids induces higher fusion events triggered by toxin-mediated RhoA inhibition. The cells respond back by rapidly regulating the overall transendothelial macroaperture surface area.

Summary: The lipids of human red blood cells infected with Plasmodium falciparum are indicative of parasite life cycle stage and sex. Sphingolipids are distributed in a sex-specific manner and are important for gametocyte viability.

Summary: We use a new set of Schizosaccharomyces pombe mutants to explore the molecular bases of lipid-linked oligosaccharide synthesis and N-glycosylation involved in congenital disorders of glycosylation type I

Summary: Efficient synthesis of the membrane phospholipid PtdIns(4,5)P2 from PtdIns depends on expression of the scaffolding protein Dvl3, which dynamically couples lipid kinases PI4KIIIα and PIP5KIγ.


Summary: HDLs, akin to their capacity for extracting cholesterol, can remove lipophilic compounds from cells, thus protecting the cells when these compounds are toxic.

Summary: There is a functional and conserved requirement for Drosophila Snazarus and its human ortholog sorting nexin 25 in autophagy. They modulate endocytosis and lipid homeostasis via specific domains.

Summary: TMEM24 reversibly localizes to ER–PM contact sites and participates in the regulation of both ER and mitochondrial Ca2+ homeostasis and in glucose-dependent ATP production in insulin-secreting cells.

Summary: Changes in cholesterol metabolism, that is, in high-density lipoprotein levels, can significantly impact leukocyte numbers via modulating bone marrow functionality.

Summary: Insertion of many lipid droplet membrane proteins into the ER is co-translational, mediated by the ER membrane protein complex and may involve topology reorientation.

Summary: In liver hepatocytes, the wrappER, a wrapping type of rough ER, simultaneously connects mitochondria and peroxisomes to form a three-organelle complex that responds to changes in hepatic lipid flux.

Summary: Different palmitoylation patterns on a lipid kinase adaptor protein control partitioning of the kinase between two spatiotemporally and functionally distinct complexes within the plasma membrane.

Summary: A product of cholesterol ester oxidation that is found in plasma of cardiovascular disease patients induces lysosome stress, culminating with the formation of vascular smooth muscle foam cells.

Summary: Myoblasts exhibit an aminophospholipid flippase activity that relies on CDC50A-dependent P4-ATPases. Loss of CDC50A compromises actin remodeling, RAC1 membrane targeting and cell fusion.

Summary: TMEM55B mediates the transport of lysosomes. We show that TMEM55B undergoes S-palmitoylation at multiple cysteine residues to mediate transport of TMEM55B from the Golgi to lysosomes.


Summary: Membrane contact sites between organelles are critical regulators of cellular function. Here we identify the highly conserved Hob proteins as novel lipid-binding proteins at ER–PM contact sites.

Summary: The resistance–nodulation–division protein Dispatched 1 expels plasma membrane cholesterol to indirectly increase Sonic hedgehog morphogen release from the cell surface.

Summary: Lipoprotein lipase is localized to large caveolar microdomains in 3T3-L1 adipocytes. In these cells, insulin regulates LPL secretion by driving trafficking of these domains via an ARF1-dependent mechanism.

Summary: Exposure to mild heat shock leads to large quantifiable changes in the cellular ultrastructure of yeast, showing the involvement of multivesicular bodies in the heat-shock response and the apparition of novel structures.

Summary: A yeast mating-based microscopic readout is used to monitor the relocalization of lipid droplet proteins. LD proteins of the two mating partners quickly re-equilibrate their localization resulting in a uniform LD population.

Summary: The acyltransferase DHHC21 is a novel component of the TCR signaling pathway that critically regulates activation and differentiation of CD4+ T cells by mediating rapid TCR-induced S-acylation of signaling proteins.

Summary: The junction between the ER membrane and lipid droplets constitutes a barrier for the transfer of ER-resident membrane-spanning proteins to the surface of lipid droplets.

Summary: Cilia of olfactory sensory neurons have a unique lipid composition. Localization of phospholipids is controlled by the INPP5E phosphatase and is involved in modulation of the odor response.

Summary: Yeast cells lacking phosphatidylserine generate protein-depleted plasma membrane domains, and vacuoles contact this domain. This is the first report of micron-scale plasma membrane domains in living cells.

Summary: The synaptotagmin-like mitochondrial-lipid-binding domain of PDZD8 transports phospholipids and ceramides at ER-late endosome/lysosome (LE/lys) contacts to promote LE/lys positioning and neurite outgrowth.


Summary: Septins are critical for cell shape. Using mutants and agents that disturb cell walls and membranes, we show that septins are involved in lipid metabolism and cell wall integrity signaling.

Summary: Ferroptosis, a unique form of lipotoxic cell death, is associated with macro-blebbing of trophoblast plasma membranes, likely representing thinning and enhanced membrane flexibility during cell death-associated swelling.


Summary: The lipophilic probes Nile Blue and Nile Red detect intracellular unsaturated free fatty acids and neutral lipids, respectively, and can be used for multiparametric imaging and flow cytometry.

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