Issues
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Cover image
Cover Image
Cover: Myoblast cells were isolated from wild-type mice at postnatal day 0, cultured, treated with a control siRNA and allowed to differentiate for 5 days. This is an immunofluorescence image of such a culture, labelled using a mixture of anti-myosin heavy chain antibodies (red), phalloidin (green) and DAPI (DNA; blue). In addition to the differentiated myofibers, which express myosin heavy chain (red), undifferentiated myoblasts and non-muscle cells, whose nuclei are labelled by DAPI (blue), can also be seen. See article by M. Agarwal et al. (jcs256008).
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RESEARCH HIGHLIGHTS
EDITORIAL
STICKY WICKET
FIRST PERSON
PERSPECTIVE
OPINION
Shaping centromeres to resist mitotic spindle forces
Summary: We integrate published data to describe a unifying mechanism for building tension between sister kinetochores. A molecular bottlebrush transforms pericentromeric chromatin into a spring due to the steric repulsion between radial loops.
SHORT REPORT
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration
Highlighted Article: The autophagy-linked FYVE protein (ALFY) localizes to cell protrusions and early endosomes, and regulates directional cell migration and attachment by modification of integrin glycosylation.
RESEARCH ARTICLES
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection
Highlighted Article: We describe novel RNP granules induced by viruses that exhibit a distinct protein and RNA composition from stress granules, and are associated with translational shut-off and antiviral activities.
Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin
Summary: COPD-patient-derived epithelia show quantifiable plasticity that is replicated by repetitive in vitro smoke exposure and is caused by increased actin polymer mass and loss of cofilin-1.
ADAD2 regulates heterochromatin in meiotic and post-meiotic male germ cells via translation of MDC1
Summary: ADAD2 is required for MDC1 translation, the reduction of which leads to abnormal heterochromatin and post-meiotic cell death, and is a key heterochromatin maintenance factor in male germ cells.
Cooperative regulation of adherens junction expansion through epidermal growth factor receptor activation
Summary:De novo junction formation activates EGFR, which in turn accelerates the formation of subsequent junctions by the same cell.
Selective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation
Summary: ESCRT-0 selectively targets aberrant proteasomes for microautophagy by recognition of proteasome ubiquitylation status to fine-tune proteasome quality control under low-glucose conditions.
Amino acids suppress macropinocytosis and promote release of CSF1 receptor in macrophages
Highlighted Article: Nine amino acids suppress CSF1-stimulated macropinocytosis by promoting the loss of CSF1 receptor, indicating a regulation by nutrients of growth factor receptor signaling.
Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway
Summary: Mutations of polycystins lead to the genetic disorder ADPKD. We show that the fission yeast polycystin homolog Pkd2p promotes cell expansion during interphase growth and antagonizes the SIN pathway during cytokinesis.
Drp1 regulates transcription of ribosomal protein genes in embryonic hearts
Highlighted Article: Deletion of Dnm1l (encoding Drp1) in the secondary heart field leads to decreased ribosomal protein gene transcription, relayed by an AMPK-SIRT7-GABPB axis, and severe abnormalities in mitochondria and cardiomyocytes in the right ventricle.
TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation
Summary: The corepressor TLE4 maintains muscle stem cell quiescence and its downregulation is crucial for Myf5 activation and differentiation.
SUMOylation modulates the function of DDX19 in mRNA export
Summary: DDX19 plays a crucial role in mRNA export at the nuclear pore complex. We find that SUMOylation enriches DDX19 at the nuclear envelope, facilitates its interaction with Gle1 and modulates the mRNA export function.
Lrrcc1 and Ccdc61 are conserved effectors of multiciliated cell function
Summary: Lrrcc1 and Ccdc61 are important for Xenopus multiciliated cell organization. Furthermore, these MCCs have a role in flushing out environmental pathogens from the skin.
The Cdc42 GTPase-activating protein Rga6 promotes the cortical localization of septin
Summary: The S. pombe Cdc42 GTPase-activating protein Rga6 promotes the localization of the septin complex to the cell cortex, where both types of proteins work in concert to regulate polarized cell growth.
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and Sadaf Farooqi, and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis

In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.