Issues
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Cover image
Cover Image
Cover: Pancreatic β-cells are essential for maintaining blood glucose balance. When blood glucose levels are increased, β-cells secrete insulin to promote glucose uptake. The image shows the distribution of the actin cytoskeleton (cyan) and insulin vesicles (red) in pancreatic β-cells. See article by I. Noordstra, C. M. van den Berg et al. (jcs259430).
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RESEARCH HIGHLIGHTS
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CELL SCIENTISTS TO WATCH
REVIEWS
Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases
Summary: This Review summarises the recent advances made in the field of MAMs and ER–mitochondria signaling in neurons and their relevance to neurodegenerative disorders.
Regulation of Wnt distribution and function by Drosophila glypicans
Summary: This Review summarizes mechanisms of extracellular Wnt distribution, with a focus on glypican-mediated mechanisms. Insights, updates and revisions to the current state of the field are described.
RESEARCH ARTICLES
Label2label: training a neural network to selectively restore cellular structures in fluorescence microscopy
Summary: Label2label is a new deep learning-based image restoration method that reduces cytosolic background signals in immunofluorescence images of cellular structures.
The nucleolar δ isoform of adapter protein SH2B1 enhances morphological complexity and function of cultured neurons
Highlighted Article: Of the four isoforms of adapter protein SH2B1, only SH2B1δ is nucleolar. SH2B1δ greatly enhances neurite complexity, a function impacted by human obesity-associated variants.
PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals
Summary: PCTAIRE1 is a mitotic kinase that localizes to the centrosomes, spindle poles and midbody during mitosis, and can serve as a potential drug target to overcome chemotherapeutic resistance.
Diverse mechanisms regulate contractile ring assembly for cytokinesis in the two-cell Caenorhabditis elegans embryo
Summary: The Ran pathway differently regulates cytokinesis in cells with different fates in the C. elegans embryo, potentially coordinating the division of germline precursor cells with their somatic neighbors.
Dynamic configurations of meiotic DNA-break hotspot determinant proteins
Summary:S. pombe linear element proteins, which are important for meiotic DNA breakage and recombination, show dynamic configurations, of which the longest form might also act in DSB repair.
Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies
Summary: We report the discovery of extracellular vesicles in the lumen of the developing tracheal respiratory system of Drosophila embryos.
Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells
Summary: Characterization of the composition of cortical complexes controlling insulin secretion, showing that their dynamics is inconsistent with assembly through liquid–liquid phase separation.
Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice
Highlighted Article: Transcription factor-like 5 is a key gene regulating spermiogenesis and male fertility, and plays these regulatory roles at transcriptional and post-transcriptional levels, respectively.
More than two populations of microtubules comprise the dynamic mitotic spindle
Highlighted Article: In contrast to the current paradigm, fluorescence dissipation experiments reveal that mitotic spindles contain multiple populations of microtubules even when kinetochore-attached microtubules are deleted.
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis

In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.