Issues
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Cover image
Cover Image
Cover: Pancreatic β-cells are essential for maintaining blood glucose balance. When blood glucose levels are increased, β-cells secrete insulin to promote glucose uptake. The image shows the distribution of the actin cytoskeleton (cyan) and insulin vesicles (red) in pancreatic β-cells. See article by I. Noordstra, C. M. van den Berg et al. (jcs259430).
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RESEARCH HIGHLIGHTS
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REVIEWS
Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases
Summary: This Review summarises the recent advances made in the field of MAMs and ER–mitochondria signaling in neurons and their relevance to neurodegenerative disorders.
Regulation of Wnt distribution and function by Drosophila glypicans
Summary: This Review summarizes mechanisms of extracellular Wnt distribution, with a focus on glypican-mediated mechanisms. Insights, updates and revisions to the current state of the field are described.
RESEARCH ARTICLES
Label2label: training a neural network to selectively restore cellular structures in fluorescence microscopy
Summary: Label2label is a new deep learning-based image restoration method that reduces cytosolic background signals in immunofluorescence images of cellular structures.
The nucleolar δ isoform of adapter protein SH2B1 enhances morphological complexity and function of cultured neurons
Highlighted Article: Of the four isoforms of adapter protein SH2B1, only SH2B1δ is nucleolar. SH2B1δ greatly enhances neurite complexity, a function impacted by human obesity-associated variants.
PCTAIRE1 promotes mitotic progression and resistance against antimitotic and apoptotic signals
Summary: PCTAIRE1 is a mitotic kinase that localizes to the centrosomes, spindle poles and midbody during mitosis, and can serve as a potential drug target to overcome chemotherapeutic resistance.
Diverse mechanisms regulate contractile ring assembly for cytokinesis in the two-cell Caenorhabditis elegans embryo
Summary: The Ran pathway differently regulates cytokinesis in cells with different fates in the C. elegans embryo, potentially coordinating the division of germline precursor cells with their somatic neighbors.
Dynamic configurations of meiotic DNA-break hotspot determinant proteins
Summary:S. pombe linear element proteins, which are important for meiotic DNA breakage and recombination, show dynamic configurations, of which the longest form might also act in DSB repair.
Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies
Summary: We report the discovery of extracellular vesicles in the lumen of the developing tracheal respiratory system of Drosophila embryos.
Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells
Summary: Characterization of the composition of cortical complexes controlling insulin secretion, showing that their dynamics is inconsistent with assembly through liquid–liquid phase separation.
Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice
Highlighted Article: Transcription factor-like 5 is a key gene regulating spermiogenesis and male fertility, and plays these regulatory roles at transcriptional and post-transcriptional levels, respectively.
More than two populations of microtubules comprise the dynamic mitotic spindle
Highlighted Article: In contrast to the current paradigm, fluorescence dissipation experiments reveal that mitotic spindles contain multiple populations of microtubules even when kinetochore-attached microtubules are deleted.
Imaging Cell Architecture and Dynamics

We are now welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Submission deadline: 1 March 2024.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'

Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Early-bird deadline is 19 January 2024.
Become a FocalPlane correspondent

FocalPlane, our community site for microscopists, is looking to appoint three scientists as correspondents who will play a key role in developing and writing content over the coming year. Interested? Find out how to become a FocalPlane correspondent here.
Sustainable Conferencing Initiative

Through our Sustainable Conferencing Grants, we promote the use of new technology and greener modes of travel. Our blog posts showcase examples of sustainability in action and share experience about how new technologies and conference formats work in practice.
Reasons to submit to Journal of Cell Science

There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.