CELL SCIENTISTS TO WATCH
Summary: This Review summarises the recent advances made in the field of MAMs and ER–mitochondria signaling in neurons and their relevance to neurodegenerative disorders.
Summary: This Review summarizes mechanisms of extracellular Wnt distribution, with a focus on glypican-mediated mechanisms. Insights, updates and revisions to the current state of the field are described.
Label2label: training a neural network to selectively restore cellular structures in fluorescence microscopy
Summary: Label2label is a new deep learning-based image restoration method that reduces cytosolic background signals in immunofluorescence images of cellular structures.
The nucleolar δ isoform of adapter protein SH2B1 enhances morphological complexity and function of cultured neurons
Highlighted Article: Of the four isoforms of adapter protein SH2B1, only SH2B1δ is nucleolar. SH2B1δ greatly enhances neurite complexity, a function impacted by human obesity-associated variants.
Summary: PCTAIRE1 is a mitotic kinase that localizes to the centrosomes, spindle poles and midbody during mitosis, and can serve as a potential drug target to overcome chemotherapeutic resistance.
Diverse mechanisms regulate contractile ring assembly for cytokinesis in the two-cell Caenorhabditis elegans embryo
Summary: The Ran pathway differently regulates cytokinesis in cells with different fates in the C. elegans embryo, potentially coordinating the division of germline precursor cells with their somatic neighbors.
Summary:S. pombe linear element proteins, which are important for meiotic DNA breakage and recombination, show dynamic configurations, of which the longest form might also act in DSB repair.
Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies
Summary: We report the discovery of extracellular vesicles in the lumen of the developing tracheal respiratory system of Drosophila embryos.
Summary: Characterization of the composition of cortical complexes controlling insulin secretion, showing that their dynamics is inconsistent with assembly through liquid–liquid phase separation.
Transcription factor-like 5 is a potential DNA- and RNA-binding protein essential for maintaining male fertility in mice
Highlighted Article: Transcription factor-like 5 is a key gene regulating spermiogenesis and male fertility, and plays these regulatory roles at transcriptional and post-transcriptional levels, respectively.
Highlighted Article: In contrast to the current paradigm, fluorescence dissipation experiments reveal that mitotic spindles contain multiple populations of microtubules even when kinetochore-attached microtubules are deleted.