Issues

Summary: Platelets are unique to mammals and produced from large polyploid megakaryocytes. Here, we hypothesize that platelets might have evolved because of a single event that led to the megakaryocyte polyploidization in a mammalian ancestor.

Summary: Intraflagellar transport trains use cargo adapters to bind certain ciliary proteins and building blocks, shuttling them from the cell body into growing cilia.

Summary: Collagen VI is expressed by pancreatic tumours and metastases in a mechanosensitive way to promote niche colonisation.

Summary: NMTN-1, the C. elegans homolog of the mammlian WD40 repeat (WDR) protein family member WDR47, is required for the ciliary structure and intraflagellar transport in the AWB neurons and AWB-mediated chemosensation.

Summary: Dvl2 forms liquid–liquid phase separated protein condensates. Ubiquitylation of Dvl2 through K63 linkage by WWP2 is required for formation of Dvl2 condensates during Wnt signalling.

Summary: Identification of structural determinants and mechanisms for LD targeting of G0S2 and HIG2, two known inhibitors of intracellular lipolysis.

Summary: Newly synthesized rhodopsin joins with rhodopsin internalized in a light-dependent manner, and they are transported together to the photoreceptive membrane (rhabdomeres) by the Rab11–Rip11–MyoV complex and nSyb.

Highlighted Article: The resolution limit of visible light has limited ultrastructure imaging in microbes. We adapt U-ExM for budding and fission yeast, thereby improving the accessibility of super-resolution microscopy of these powerful genetic models.