Issues

Summary: This Cell Science at a Glance provides insights into how mitochondria are recognized and targeted to lysosomes for degradation under different physiological conditions to maintain cellular homeostasis.

Summary: Mitochondria-associated niches are a new integrative perspective to signaling that is regulated by interorganelle interactions. We highlight molecule exchanges in these niches and their implications for health and disease.

Summary: LRRK1 is recruited to damaged mitochondria by interacting with ATG13, a component of the ULK complex, during Parkin-mediated mitophagy and initiates mitophagosome formation via Rab7 Ser-72 phosphorylation.

Summary: Oxidized RNA bodies compartmentalize quality control pathways that rescue stalled ribosomes on defective mRNAs, joining a class of RNA granules that handle mRNAs in specific phases of translation.

Highlighted Article: NOC1 is a nucleolar protein necessary for rRNA maturation and protein synthesis. Its reduction results in apoptosis and cell competition accompanied by upregulation of Xrp1 and of DILP8.

Summary: mTORC2 is a master regulator of multiple signaling pathways; however, its physiological roles are poorly characterized. Here, we identify a surprising new mechanism for its role in electrolyte homeostasis.

Summary: Basal mammary epithelial cells exhibit remarkable plasticity and self-renewal activity. Adhesion of basal cells to laminin α5-containing matrix controls their function by directing them towards a luminal cell fate.

Highlighted Article: ER exit site (ERES) proteins undergo stress-induced redistribution into membraneless Sec bodies in mammals. This depletes them from the ER membrane, which impairs ER exit.