CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: A Review of how cells with a cell wall, especially fungi and plants, sense and transduce surface forces to regulate growth and morphogenesis.
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner
Summary: A newly described mechanism for human Tfh1 polarization with possible implications in infection.
LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport
Highlighted Article: Phosphorylation of NDEL1 Ser-155 by LRRK1 promotes binding of NDEL1 to the dynein-2 intermediate chains, which is required for cilia disassembly via dynein-2-mediated retrograde intraflagellar transport.
Δ133p53 coordinates ECM-driven morphogenesis and gene expression in three-dimensional mammary epithelial acini
Summary: A small p53 isoform responds specifically laminin-111, a key extracellular matrix component, and regulates the expression of extracellular matrix molecules required to establish correct form and function.
Highlighted Article: The impact of the S. cerevisiae multifunctional mitochondria and dynein anchor protein Num1 on mitochondrial function extends beyond its role in mitochondria–PM tethering to its role in anchoring dynein at the cell cortex.
Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development
Summary: Hspa8 (also known as Hsc70), an essential protein for cell survival, has tissue-specific roles via induction of the unfolded protein response in the regulation of zebrafish embryonic development.
MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation
Summary: Mutated in colorectal cancer (MCC) localizes to the centrosome in intestinal crypt cells. Upon cell differentiation, MCC is redeployed to the apical ncMTOC. This event is coordinated by CK1δ/ε phosphorylation.