Issues
-
Cover image
Cover Image
Cover: The coiled-coil protein mutated in colorectal cancer (MCC) localises to the centrosome in proliferating cells in intestinal crypts. Upon terminal differentiation, MCC redeploys to non-centrosomal apical sites within epithelial cells of the villi – a process that is governed by phosphorylation of MCC mediated by casein kinase 1δ and ε. The image shows a panoramic cross-section view of a mouse small intestinal villus, revealing MCC protein (red) distribution at the apical membrane, with β-catenin (green) outlining the lateral cell membrane. Nuclei are stained using Hoechst 33342 (blue). See article by L. B. Tomaz et al. (jcs259272).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Gut homeostasis at a glance
Summary: Here, we describe the function and structure of the intestine and discuss the turnover of the epithelium and role of mesenchymal cells and immune cells.
REVIEW
Mechanobiology of the cell wall – insights from tip-growing plant and fungal cells
Summary: A Review of how cells with a cell wall, especially fungi and plants, sense and transduce surface forces to regulate growth and morphogenesis.
RESEARCH ARTICLES
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner
Summary: A newly described mechanism for human Tfh1 polarization with possible implications in infection.
LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport
Highlighted Article: Phosphorylation of NDEL1 Ser-155 by LRRK1 promotes binding of NDEL1 to the dynein-2 intermediate chains, which is required for cilia disassembly via dynein-2-mediated retrograde intraflagellar transport.
Δ133p53 coordinates ECM-driven morphogenesis and gene expression in three-dimensional mammary epithelial acini
Summary: A small p53 isoform responds specifically laminin-111, a key extracellular matrix component, and regulates the expression of extracellular matrix molecules required to establish correct form and function.
Loss of Num1-mediated cortical dynein anchoring negatively impacts respiratory growth
Highlighted Article: The impact of the S. cerevisiae multifunctional mitochondria and dynein anchor protein Num1 on mitochondrial function extends beyond its role in mitochondria–PM tethering to its role in anchoring dynein at the cell cortex.
Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development
Summary: Hspa8 (also known as Hsc70), an essential protein for cell survival, has tissue-specific roles via induction of the unfolded protein response in the regulation of zebrafish embryonic development.
MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation
Summary: Mutated in colorectal cancer (MCC) localizes to the centrosome in intestinal crypt cells. Upon cell differentiation, MCC is redeployed to the apical ncMTOC. This event is coordinated by CK1δ/ε phosphorylation.
FIRST PERSON
PUBLISHER'S NOTE
Expression of Concern: Spatiotemporal dynamics of p21CDKN1A protein recruitment to DNA-damage sites and interaction with proliferating cell nuclear antigen
CORRECTION
Call for papers - Cilia and Flagella: from Basic Biology to Disease

We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The final deadline for registration is 28 February 2025.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
How to investigate GPCR signalling in cells

Abigail Pearce and colleagues provide a critical overview of new, state-of-the-art approaches used to quantitatively study G protein-coupled receptor signalling in cells.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).