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RESEARCH HIGHLIGHTS

CELL SCIENTISTS TO WATCH

CELL SCIENCE AT A GLANCE

Summary: Here, we describe the function and structure of the intestine and discuss the turnover of the epithelium and role of mesenchymal cells and immune cells.

REVIEW

Summary: A Review of how cells with a cell wall, especially fungi and plants, sense and transduce surface forces to regulate growth and morphogenesis.

RESEARCH ARTICLES

REVIEW COMMONS TRANSFER

Summary: A newly described mechanism for human Tfh1 polarization with possible implications in infection.

Highlighted Article: Phosphorylation of NDEL1 Ser-155 by LRRK1 promotes binding of NDEL1 to the dynein-2 intermediate chains, which is required for cilia disassembly via dynein-2-mediated retrograde intraflagellar transport.

Summary: A small p53 isoform responds specifically laminin-111, a key extracellular matrix component, and regulates the expression of extracellular matrix molecules required to establish correct form and function.

Highlighted Article: The impact of the S. cerevisiae multifunctional mitochondria and dynein anchor protein Num1 on mitochondrial function extends beyond its role in mitochondria–PM tethering to its role in anchoring dynein at the cell cortex.

Summary: Hspa8 (also known as Hsc70), an essential protein for cell survival, has tissue-specific roles via induction of the unfolded protein response in the regulation of zebrafish embryonic development.

Summary: Mutated in colorectal cancer (MCC) localizes to the centrosome in intestinal crypt cells. Upon cell differentiation, MCC is redeployed to the apical ncMTOC. This event is coordinated by CK1δ/ε phosphorylation.

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