Issues

Summary: The Z-disc is a massive and essential component of myofibrils. We use data from insects to present a comprehensive review of the assembly, components and functions of the Z-disc.

Summary: This Review discusses the current structural understanding of one key regulator of the focal adhesion complex, focal adhesion kinase (FAK), and how it communicates with mechanical parts to promote cellular movement.

Summary: An analysis of publicly available sc-RNAseq data from human and mouse epidermis to determine foundational principles and emerging paradigms regarding the significance of keratin gene expression.

Summary: The transcription factor AHR drives the expression of the actin-severing protein scinderin, which, in turn, promotes nuclear translocation of β-catenin, suggesting a novel mechanism by which AHR promotes growth of colon cancer cells.

Highlighted Article: PP2A(B′) holoenzymes, in addition to STRIPAK, promote Yorkie activity by antagonizing Salvador-Rassf-Hippo signaling to maintain the morphology of the Drosophila eye disc epithelium.

Summary: MLL regulates cell shape, the actin cytoskeleton and cell migration by affecting the homeostasis of small Rho GTPases and plays a central regulatory role in Rho/Rac/CDC42 signalling pathways.

Highlighted Article: We identify signaling pathways activated by a phagocytosis receptor that induce cell death in neighboring cells.

Summary: ETS-1 regulates basement membrane remodeling and cathepsin cell population during planarian homeostasis and regeneration.

Summary: We characterized SHARPIN phosphorylation by mass spectrometry and in vitro kinase assay. Our results identify S146 as a phosphorylation switch defining ARP2/3 interaction and cancer cell invasion.