Issues

Summary: An overview of centrosome 3D organization, describing molecular asymmetries between the mother (mature) and the daughter (immature) centrioles, and how these are acquired in synchrony with the cell cycle.

Summary: Integrin α6β4 is recruited with vimentin to perinuclear focal and fibrillar adhesions indicating how integrin α6β4 cooperates with other integrins to drive migration and invasive growth.

Summary: Endothelial cells heterogeneity is key to complex collective functions and cell behaviour. We developed a novel image-based endothelial cell profiling tool and quantified heterogeneity in NOTCH signalling in monolayers.

Highlighted Article: The histone demethylase DPY-21 has catalytic and non-catalytic roles in condensin DC-mediated X chromosome repression. The non-catalytic activity regulates dynamics of condensin DC binding to X chromosomes.

Summary: The oncoprotein PRL regulates epithelial cell density by driving apoptosis at confluence, which is important for convergent extension during early development in vertebrate embryos.

Summary: We describe the molecular interactions of the junctin luminal tail with the macromolecular complex that regulates Ca²⁺ release from the sarcoplasmic reticulum in skeletal muscle.

Highlighted Article: Contrary to current models, KRIT1 does not require binding to ICAP1α and Rap1, or junctional localization, to stabilize the endothelial barrier. Instead, self-interaction and/or β1 integrin activation are critical elements of KRIT1 signaling.

Summary: Alzheimer's disease-associated isoform APOE4 accumulates in lysosomes and dysregulates autophagic flux. APOE can enter the lysosome through autophagy requiring LAMP2A, a receptor for chaperone-mediated autophagy.

Summary: Chiffon within the Gcn5-containing CHAT complex plays key roles in embryonic gene expression and histone H3 acetylation in Drosophila.

Highlighted Article: SAF-A contributes to the formation of open chromatin structure. We have discovered that SAF-A supports DNA replication at multiple steps.

Highlighted Article: The ubiquitin ligase APC/C is required for anaphase execution and localizes to the centrosome during mitosis. Its function is to remove Cep152, an inhibitor of microtubule nucleation, from the centrosome.

Summary: CaM mutations associated with human cardiac arrhythmia syndromes result in CaM dysfunction, which appears to be a key driver of the disease, with different mutants acting via different mechanisms.

Summary: Expression, mutagenic and cytological analyses identify cyclophilin A as an important regulator of Twist1 phosphorylation and stability that acts as an inhibitor of A549 cell apoptosis.

Summary: Mitochondrial hyperfusion caused by the CMT2A-linked R364W mutation of MFN2 is the result of altered interactions between R364W-MFN2 and MITOL, which lead to enhanced proteasomal degradation of DRP1.