Issues

Summary: Cilia are signaling antennae that also secrete extracellular vesicles packaged with signaling proteins. We review the mechanism of biogenesis and biological functions of ciliary extracellular vesicles.

Summary: We review recent advances in phosphoproteomic, structural and research tool development for serine/threonine-specific phosphoprotein phosphatases, and insights gained into their substrate specificity and regulation.

Summary: Expression of TAN1 in the root meristematic zone rescues cell-file-rotation defects in tan1 air9 mutant plants, suggesting that defects that occur in mitosis influence the organization of non-dividing cells.

Summary: Extracellular niche cues involving matrix rigidity and focal adhesion entrain the circadian clock via modulation of actin cytoskeleton dynamics and MRTF/SRF-mediated transcription.

Summary: We identify the oncogenic transcription factor FOXQ1 as a differential regulator of Wnt target gene expression, which may be of particular importance for Wnt-driven colorectal cancer.

Highlighted Article: Cell size varies between cell types but is tightly regulated. We identify the methyltransferase SETD2 as a negative regulator of global protein synthesis rates and cell size.

Summary: Kinetic analysis of actin recruitment during Chlamydia trachomatis invasion reveals TarP as the major contributor relative to TmeA, via its ability to facilitate collaboration between the actin nucleators formin 1 and Arp2/3.

Summary: Protein targeting to the nucleolus in Trypanosoma brucei is mediated by positive charge, indicating a probable eukaryote-wide mechanism, and contributes to the sorting of mitochondrial from cytoplasmic ribosomes.

Highlighted Article: Release of HIV-1 from macrophages is promoted by reorganization of an actin cytoskeleton associated with the viral compartment, either at the steady-state or in cells under mechanical constraints.

Summary: Systemic deletion of Foxc1 and Foxc2 2 days after the onset of metanephros development (E13.5) resulted in the epithelialization of nephron progenitors and ectopic formation of renal vesicles at E18.5.