CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Emerging insights into serine/threonine-specific phosphoprotein phosphatase function and selectivity
Summary: We review recent advances in phosphoproteomic, structural and research tool development for serine/threonine-specific phosphoprotein phosphatases, and insights gained into their substrate specificity and regulation.
Defects in division plane positioning in the root meristematic zone affect cell organization in the differentiation zone
Summary: Expression of TAN1 in the root meristematic zone rescues cell-file-rotation defects in tan1 air9 mutant plants, suggesting that defects that occur in mitosis influence the organization of non-dividing cells.
The actin cytoskeleton-MRTF/SRF cascade transduces cellular physical niche cues to entrain the circadian clock
Summary: Extracellular niche cues involving matrix rigidity and focal adhesion entrain the circadian clock via modulation of actin cytoskeleton dynamics and MRTF/SRF-mediated transcription.
Summary: We identify the oncogenic transcription factor FOXQ1 as a differential regulator of Wnt target gene expression, which may be of particular importance for Wnt-driven colorectal cancer.
Highlighted Article: Cell size varies between cell types but is tightly regulated. We identify the methyltransferase SETD2 as a negative regulator of global protein synthesis rates and cell size.
Distinct roles of the Chlamydia trachomatis effectors TarP and TmeA in the regulation of formin and Arp2/3 during entry
Summary: Kinetic analysis of actin recruitment during Chlamydia trachomatis invasion reveals TarP as the major contributor relative to TmeA, via its ability to facilitate collaboration between the actin nucleators formin 1 and Arp2/3.
Nucleolar targeting in an early-branching eukaryote suggests a general mechanism for ribosome protein sorting
Summary: Protein targeting to the nucleolus in Trypanosoma brucei is mediated by positive charge, indicating a probable eukaryote-wide mechanism, and contributes to the sorting of mitochondrial from cytoplasmic ribosomes.
Release of HIV-1 particles from macrophages is promoted by an anchored cytoskeleton and driven by mechanical constraints
Highlighted Article: Release of HIV-1 from macrophages is promoted by reorganization of an actin cytoskeleton associated with the viral compartment, either at the steady-state or in cells under mechanical constraints.
Foxc1 and Foxc2 are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney
Summary: Systemic deletion of Foxc1 and Foxc2 2 days after the onset of metanephros development (E13.5) resulted in the epithelialization of nephron progenitors and ectopic formation of renal vesicles at E18.5.