Issues

Summary: Phospholipase Cβ1 relays Ca²⁺ signals in response to hormones and neurotransmitters, but recent studies reveal additional unexpected functions in protein translation and the cell cycle, which we describe here.

Summary: A review of recent insights into the roles of the extracellular matrix molecule tenascin-C in tumorigenesis, tumor immunity and metastasis, and how this could be exploited for cancer disease management.

Highlighted Article: This study reveals a noncanonical role of AMP-activated kinase in which the α subunit C-terminal regulatory domain serves as a guanine-nucleotide-exchange factor for Arf6 during glucose deprivation.

Highlighted Article: Single-cell time-lapse microscopy of budding yeast reveals oscillations in the activity of TORC1 and PKA signaling pathways under constant external conditions.

Highlighted Article: The cysteine-rich protein CRIPT regulates spindle movement during mitosis and the expression of CRIPT with cysteine mutations completely blocks spindle disassembly in human cells.

Summary:Dictyostelium discoideum cells at high cell densities use extracellular polyphosphate to alter membrane properties and inhibit exocytosis of undigested or partially digested nutrients using a signal transduction pathway.

Summary: RABL3 cooperates with RAB11 to regulate ciliary vesicle formation during early ciliogenesis in human cells.

Summary: Vacuolar localization of S. cerevisiae Pib2, a key TORC1 regulator that both inhibits and activates TORC1 activity via conserved regions, is key for recovery and cell growth following rapamycin exposure.

Summary: Visualization of tropomyosin in living yeasts and mammalian cells.

Summary: Live-imaging assays to track endocytosis and monitor trafficking dynamics in the zebrafish neuroepithelium show involvement of the inositol phosphatase Ocrl, a protein linked to Lowe syndrome, in this process.