CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: Phospholipase Cβ1 relays Ca2+ signals in response to hormones and neurotransmitters, but recent studies reveal additional unexpected functions in protein translation and the cell cycle, which we describe here.
Summary: A review of recent insights into the roles of the extracellular matrix molecule tenascin-C in tumorigenesis, tumor immunity and metastasis, and how this could be exploited for cancer disease management.
Highlighted Article: This study reveals a noncanonical role of AMP-activated kinase in which the α subunit C-terminal regulatory domain serves as a guanine-nucleotide-exchange factor for Arf6 during glucose deprivation.
TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle
Highlighted Article: Single-cell time-lapse microscopy of budding yeast reveals oscillations in the activity of TORC1 and PKA signaling pathways under constant external conditions.
Highlighted Article: The cysteine-rich protein CRIPT regulates spindle movement during mitosis and the expression of CRIPT with cysteine mutations completely blocks spindle disassembly in human cells.
Dictyostelium discoideum cells retain nutrients when the cells are about to outgrow their food source
Summary:Dictyostelium discoideum cells at high cell densities use extracellular polyphosphate to alter membrane properties and inhibit exocytosis of undigested or partially digested nutrients using a signal transduction pathway.
Summary: Vacuolar localization of S. cerevisiae Pib2, a key TORC1 regulator that both inhibits and activates TORC1 activity via conserved regions, is key for recovery and cell growth following rapamycin exposure.
TOOLS AND RESOURCES
Summary: Visualization of tropomyosin in living yeasts and mammalian cells.
Summary: Live-imaging assays to track endocytosis and monitor trafficking dynamics in the zebrafish neuroepithelium show involvement of the inositol phosphatase Ocrl, a protein linked to Lowe syndrome, in this process.