Issues
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Cover image
Cover Image
Cover: Image showing HeLa cells expressing DsRed-tagged mutant CRIPT (CRIPTC3Y; red) with immunolabelling of α-tubulin (green). DNA is counterstained by DAPI (blue). See article by K. Xu et al. (jcs259657).
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RESEARCH HIGHLIGHTS
STICKY WICKET
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Multiple functions of phospholipase Cβ1 at a glance
Summary: Phospholipase Cβ1 relays Ca2+ signals in response to hormones and neurotransmitters, but recent studies reveal additional unexpected functions in protein translation and the cell cycle, which we describe here.
REVIEW
Advances on the roles of tenascin-C in cancer
Summary: A review of recent insights into the roles of the extracellular matrix molecule tenascin-C in tumorigenesis, tumor immunity and metastasis, and how this could be exploited for cancer disease management.
SHORT REPORT
AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation
Highlighted Article: This study reveals a noncanonical role of AMP-activated kinase in which the α subunit C-terminal regulatory domain serves as a guanine-nucleotide-exchange factor for Arf6 during glucose deprivation.
RESEARCH ARTICLES
TORC1 and PKA activity towards ribosome biogenesis oscillates in synchrony with the budding yeast cell cycle
Highlighted Article: Single-cell time-lapse microscopy of budding yeast reveals oscillations in the activity of TORC1 and PKA signaling pathways under constant external conditions.
Mitotic spindle disassembly in human cells relies on CRIPT having hierarchical redox signals
Highlighted Article: The cysteine-rich protein CRIPT regulates spindle movement during mitosis and the expression of CRIPT with cysteine mutations completely blocks spindle disassembly in human cells.
Dictyostelium discoideum cells retain nutrients when the cells are about to outgrow their food source
Summary:Dictyostelium discoideum cells at high cell densities use extracellular polyphosphate to alter membrane properties and inhibit exocytosis of undigested or partially digested nutrients using a signal transduction pathway.
The atypical small GTPase RABL3 interacts with RAB11 to regulate early ciliogenesis in human cells
Summary: RABL3 cooperates with RAB11 to regulate ciliary vesicle formation during early ciliogenesis in human cells.
Conserved Pib2 regions have distinct roles in TORC1 regulation at the vacuole
Summary: Vacuolar localization of S. cerevisiae Pib2, a key TORC1 regulator that both inhibits and activates TORC1 activity via conserved regions, is key for recovery and cell growth following rapamycin exposure.
TOOLS AND RESOURCES
mNG-tagged fusion proteins and nanobodies to visualize tropomyosins in yeast and mammalian cells
Summary: Visualization of tropomyosin in living yeasts and mammalian cells.
Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium
Summary: Live-imaging assays to track endocytosis and monitor trafficking dynamics in the zebrafish neuroepithelium show involvement of the inositol phosphatase Ocrl, a protein linked to Lowe syndrome, in this process.
FIRST PERSON
PUBLISHER'S NOTE
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
The spatial choreography of mRNA biosynthesis

In their Review, André Ventura-Gomes and Maria Carmo-Fonseca detail the latest research progress and technological advancements that are helping to unlock how nuclear organisation underpins control of gene transcription and pre-mRNA splicing.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
The emerging roles of the endoplasmic reticulum in mechanosensing and mechanotransduction

In their Review, Jonathan Townson and Cinzia Progida highlight recently emerging evidence for a role of the endoplasmic reticulum in enabling a cell to sense and respond to changes in the extracellular mechanical environment.