Issues
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Cover image
Cover Image
Cover: Winning image of the European Light Microscopy Initiative-FocalPlane image contest jury prize, ‘Electric Love’, taken by Ciarán Butler-Hallissey, PhD student in the NeuroCyto lab at the Institute of NeuroPhysiopathology, Aix-Marseille University, Marseille, France. The image shows Cos-7 cells stained for actin (blue), microtubules (yellow) and DNA (red), and was captured using a Zeiss Apotome.
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RESEARCH HIGHLIGHTS
STICKY WICKET
CELL SCIENTISTS TO WATCH
PERSPECTIVE
CELL SCIENCE AT A GLANCE
Necroptosis at a glance
Summary: This Cell Science at a Glance and the accompanying poster provide a comprehensive overview of recent advances in the molecular regulation of necroptosis and its roles in pathogen defense and tissue homeostasis.
REVIEW
Cilia proteins getting to work – how do they commute from the cytoplasm to the base of cilia?
Summary: This Review discusses how ciliary proteins are transported through the cytoplasm to the base of cilia, an underappreciated topic in ciliary cell biology.
SHORT REPORTS
Deltex modulates Dpp morphogen gradient formation and affects Dpp signaling in Drosophila
Summary: Deltex genetically interacts with different alleles of Dpp pathway components during wing development and modulates Dpp signaling output by facilitating formation of the Dpp morphogen gradient.
Differential requirement for DICER1 activity during the development of mitral and tricuspid valves
Summary: DICER1 activity is only essential for mitral valve development, whereas it is dispensable for other valves; therefore miRNA-mediated gene regulation is differentially required to regulate valve development.
RESEARCH ARTICLES
The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins
Summary: The serine/threonine kinase MINK1 phosphorylates prometastatic proteins in triple-negative breast cancer and may represent a suitable target for the treatment of this aggressive cancer subtype.
Interaction between VPS13A and the XK scramblase is important for VPS13A function in humans
Summary: Mutations in VPS13A and XK cause related neurodegenerative disorders. A pathological VPS13A mutation disrupts binding of the VPS13A and XK proteins, suggesting a common basis of both diseases.
iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells
Summary: Oncogenic KRAS mutations lead to phosphorylation of iRhom2, driving a tumour-promoting feedback loop of ADAM17-dependent ERBB signalling. Cancer-associated mutations in iRhom2 enhance this signalling.
Proteasome granule formation is regulated through mitochondrial respiration and kinase signaling
Highlighted Article: Mitochondrial respiration regulates proteasome granule formation, which requires the cell-integrity MAPK pathway and Snf1 kinase as regulatory factors in Saccharomyces cerevisiae.
PDGFR dimer-specific activation, trafficking and downstream signaling dynamics
Summary: A novel bimolecular fluorescence complementation approach reveals differences in the timing and extent of PDGFRα versus PDGFRβ homodimer activation, trafficking and downstream signaling.
TGFBR3 supports anoikis through suppressing ATF4 signaling
Summary: Extracellular matrix detachment induces the expression of TGFBR3, which activates apoptosis pathways and suppresses the integrated stress response. TGFBR3 loss promotes cell survival through resistance to anoikis.
Modest increase of KIF11 expression exposes fragilities in the mitotic spindle, causing chromosomal instability
Highlighted Article: Using a high-throughput, single-cell, image-based pipeline to detect chromosomal instability, we found that modest KIF11 upregulation compromised mitotic spindle integrity and induced aneuploidy via micronuclei formation.
Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae
Summary: In S. cerevisiae, TOR complex 2 (TORC2) contributes to TORC2–Ypk1/2 and TORC2–Pkc1 signaling. Phosphatidylserine and phospholipase C mediate the activation of TORC2 signaling.
FIRST PERSON
Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Mitochondria–membranous organelle contacts at a glance
Antigoni Diokmetzidou and Luca Scorrano provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and functions of such contacts.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 6 June 2025 (decision by week commencing 28 July 2025) and 5 September 2025 (decision by week commencing 20 October 2025).
JCS fast-track option
Have a paper that has been reviewed elsewhere? JCS is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision within one week.
