Issues

Summary: This Cell Science at a Glance and the accompanying poster provide a comprehensive overview of recent advances in the molecular regulation of necroptosis and its roles in pathogen defense and tissue homeostasis.

Summary: This Review discusses how ciliary proteins are transported through the cytoplasm to the base of cilia, an underappreciated topic in ciliary cell biology.

Summary: Deltex genetically interacts with different alleles of Dpp pathway components during wing development and modulates Dpp signaling output by facilitating formation of the Dpp morphogen gradient.

Summary: DICER1 activity is only essential for mitral valve development, whereas it is dispensable for other valves; therefore miRNA-mediated gene regulation is differentially required to regulate valve development.

Summary: The serine/threonine kinase MINK1 phosphorylates prometastatic proteins in triple-negative breast cancer and may represent a suitable target for the treatment of this aggressive cancer subtype.

Summary: Mutations in VPS13A and XK cause related neurodegenerative disorders. A pathological VPS13A mutation disrupts binding of the VPS13A and XK proteins, suggesting a common basis of both diseases.

Summary: Oncogenic KRAS mutations lead to phosphorylation of iRhom2, driving a tumour-promoting feedback loop of ADAM17-dependent ERBB signalling. Cancer-associated mutations in iRhom2 enhance this signalling.

Highlighted Article: Mitochondrial respiration regulates proteasome granule formation, which requires the cell-integrity MAPK pathway and Snf1 kinase as regulatory factors in Saccharomyces cerevisiae.

Summary: A novel bimolecular fluorescence complementation approach reveals differences in the timing and extent of PDGFRα versus PDGFRβ homodimer activation, trafficking and downstream signaling.

Summary: Extracellular matrix detachment induces the expression of TGFBR3, which activates apoptosis pathways and suppresses the integrated stress response. TGFBR3 loss promotes cell survival through resistance to anoikis.

Highlighted Article: Using a high-throughput, single-cell, image-based pipeline to detect chromosomal instability, we found that modest KIF11 upregulation compromised mitotic spindle integrity and induced aneuploidy via micronuclei formation.

Summary: In S. cerevisiae, TOR complex 2 (TORC2) contributes to TORC2–Ypk1/2 and TORC2–Pkc1 signaling. Phosphatidylserine and phospholipase C mediate the activation of TORC2 signaling.