CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: This Review discusses how ciliary proteins are transported through the cytoplasm to the base of cilia, an underappreciated topic in ciliary cell biology.
Summary: Deltex genetically interacts with different alleles of Dpp pathway components during wing development and modulates Dpp signaling output by facilitating formation of the Dpp morphogen gradient.
Summary: DICER1 activity is only essential for mitral valve development, whereas it is dispensable for other valves; therefore miRNA-mediated gene regulation is differentially required to regulate valve development.
Summary: The serine/threonine kinase MINK1 phosphorylates prometastatic proteins in triple-negative breast cancer and may represent a suitable target for the treatment of this aggressive cancer subtype.
Summary: Mutations in VPS13A and XK cause related neurodegenerative disorders. A pathological VPS13A mutation disrupts binding of the VPS13A and XK proteins, suggesting a common basis of both diseases.
Summary: Oncogenic KRAS mutations lead to phosphorylation of iRhom2, driving a tumour-promoting feedback loop of ADAM17-dependent ERBB signalling. Cancer-associated mutations in iRhom2 enhance this signalling.
Summary: Mitochondrial respiration regulates proteasome granule formation, which requires the cell-integrity MAPK pathway and Snf1 kinase as regulatory factors in Saccharomyces cerevisiae.
Summary: A novel bimolecular fluorescence complementation approach reveals differences in the timing and extent of PDGFRα versus PDGFRβ homodimer activation, trafficking and downstream signaling.
Summary: Extracellular matrix detachment induces the expression of TGFBR3, which activates apoptosis pathways and suppresses the integrated stress response. TGFBR3 loss promotes cell survival through resistance to anoikis.
Modest increase of KIF11 expression exposes fragilities in the mitotic spindle, causing chromosomal instability
Summary: Using a high-throughput, single-cell, image-based pipeline to detect chromosomal instability, we found that modest KIF11 upregulation compromised mitotic spindle integrity and induced aneuploidy via micronuclei formation.
Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae
Summary: In S. cerevisiae, TOR complex 2 (TORC2) contributes to TORC2–Ypk1/2 and TORC2–Pkc1 signaling. Phosphatidylserine and phospholipase C mediate the activation of TORC2 signaling.