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RESEARCH HIGHLIGHTS

STICKY WICKET

OBITUARY

REVIEW

Summary: We explore the concept of cancer as a disease that involves abnormal regulation of cellular quiescence at every step, from malignant transformation to metastatic outgrowth.

RESEARCH ARTICLES

Highlighted Article: Apicomplexan acetyl-CoA transporter 1 is indispensable for parasite development and transmission. This role is unrelated to the extensive acetylation of secreted proteins identified in apicomplexans.

REVIEW COMMONS TRANSFER

Summary: Threonine phosphorylation at the juxtamembrane domain of EGFR is a critical step in shifting the role of EGFR from a kinase to a scaffold for signal transduction.

Summary: Promoter-proximal RNAPII stalling primes quiescent myoblasts for cell cycle re-entry. Surprisingly, Aff4, a component of the super elongation complex, is implicated in restraining the G0-G1 transition.

Summary: Identification of a two-step mechanism of CLIC1 membrane insertion based on Zn2+ binding and pH activation of Cl efflux.

Summary: Metformin suppresses senescence via inactivating the cGAS-STING pathway through inducing autophagy, implying a new application for metformin in cGAS-STING pathway-related diseases.

Summary: p53 amyloid formation alters key cellular pathways to induce oncogenic traits leading to cellular transformation.

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