Issues

Summary: Comprehensive description of optical tweezer experiments as used to study the importance of mechanical forces in cell biology and physiology.

Summary: We explore the concept of cancer as a disease that involves abnormal regulation of cellular quiescence at every step, from malignant transformation to metastatic outgrowth.

Highlighted Article: Rac-dependent actin remodeling can occur in the absence of WAVE regulatory complex, triggered by active Cdc42. WAVE regulatory complex-independent actin structures harbor Arp2/3 complex but not VASP.

Summary: xCT-overexpressing cancer cells are highly vulnerable to glucose deprivation owing to a redox-dependent AMPK inactivation, leading to failure of metabolic adaptation.

Highlighted Article: Apicomplexan acetyl-CoA transporter 1 is indispensable for parasite development and transmission. This role is unrelated to the extensive acetylation of secreted proteins identified in apicomplexans.

Highlighted Article: Threonine phosphorylation at the juxtamembrane domain of EGFR is a critical step in shifting the role of EGFR from a kinase to a scaffold for signal transduction.

Summary: Promoter-proximal RNAPII stalling primes quiescent myoblasts for cell cycle re-entry. Surprisingly, Aff4, a component of the super elongation complex, is implicated in restraining the G₀-G₁ transition.

Summary: Identification of a two-step mechanism of CLIC1 membrane insertion based on Zn²⁺ binding and pH activation of Cl⁻ efflux.

Summary: Metformin suppresses senescence via inactivating the cGAS-STING pathway through inducing autophagy, implying a new application for metformin in cGAS-STING pathway-related diseases.

Summary: p53 amyloid formation alters key cellular pathways to induce oncogenic traits leading to cellular transformation.