Issues

Summary: A review of the role of appressoria in fungal infections of plants. Appressoria are specialised infection cells that facilitate host cell invasion.

Summary: Affimers and nanobodies are small binding proteins that are becoming widely used in cell biology in place of antibodies. We explain how Affimers and nanobodies are generated, used and their advantages for super-resolution imaging.

Summary: The mammalian CTLH complex forms different molecular mass complexes in the nucleus and the cytoplasm and interacts with different proteins in each compartment, and its stability in the nucleus depends on WDR26.

Summary: Combining cortisone with the chemotherapy vinorelbine enhances the assembly of stress granules that are less likely to be cleared from the cells, augmenting vinorelbine-induced cell death.

Summary: Mucinous colorectal carcinoma tumors maintain a robust apico-basolateral polarity with two distinct topologies – either a conventional ‘apical-in’ polarity or an inverted ‘apical-out’ topology.

Summary: The laminar shear stress-sensitive miR-29b-3p/CX3CL1 axis significantly inhibits monocyte adhesion to activated human aortic endothelial cells, and alleviates local inflammation and plaque formation in ApoE^−/− mice fed a high-fat diet.

Highlighted Article: Cp110 and Cep97, proteins that are normally located at the distal-end of the centriole, appear able to influence the assembly of the centriole cartwheel at the proximal end.

Summary: Live imaging of the Drosophila intestinal epithelium reveals that stem cells and their terminal progeny exhibit distinct, fate-specific Ca²⁺ oscillations that are paced independently of each other.

Highlighted Article: Rac1 GTPase, the actin cytoskeleton and microtubules are involved in endophilin-A3-mediated clathrin-independent endocytosis, with a role for myosin 2A, kinesin KIF5B and kinesin-14 family members.

Highlighted Article: Expansion microscopy provides quantitative insight into the impact of chromatin modifiers on spatiotemporal organisation of the DNA repair proteins BRCA1, 53BP1 and RAD51 at a resolution of 65–70 nm.