Issues
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Cover image
Cover Image
Cover: Two organoids made from the patient-derived xenograft mucinous colorectal carcinoma cells stained with DAPI (green), and for Epcam (blue) and actin (pink). See article by Charlotte Canet-Jourdan (jcs259256).
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RESEARCH HIGHLIGHTS
STICKY WICKET
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The appressorium at a glance
Summary: A review of the role of appressoria in fungal infections of plants. Appressoria are specialised infection cells that facilitate host cell invasion.
REVIEW
Affimers and nanobodies as molecular probes and their applications in imaging
Summary: Affimers and nanobodies are small binding proteins that are becoming widely used in cell biology in place of antibodies. We explain how Affimers and nanobodies are generated, used and their advantages for super-resolution imaging.
RESEARCH ARTICLES
Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex
Summary: The mammalian CTLH complex forms different molecular mass complexes in the nucleus and the cytoplasm and interacts with different proteins in each compartment, and its stability in the nucleus depends on WDR26.
Glucocorticoids enhance chemotherapy-driven stress granule assembly and impair granule dynamics, leading to cell death
Summary: Combining cortisone with the chemotherapy vinorelbine enhances the assembly of stress granules that are less likely to be cleared from the cells, augmenting vinorelbine-induced cell death.
Patient-derived organoids identify an apico-basolateral polarity switch associated with survival in colorectal cancer
Summary: Mucinous colorectal carcinoma tumors maintain a robust apico-basolateral polarity with two distinct topologies – either a conventional ‘apical-in’ polarity or an inverted ‘apical-out’ topology.
Laminar shear stress alleviates monocyte adhesion and atherosclerosis development via miR-29b-3p/CX3CL1 axis regulation
Summary: The laminar shear stress-sensitive miR-29b-3p/CX3CL1 axis significantly inhibits monocyte adhesion to activated human aortic endothelial cells, and alleviates local inflammation and plaque formation in ApoE−/− mice fed a high-fat diet.
Centriole distal-end proteins CP110 and Cep97 influence centriole cartwheel growth at the proximal end
Highlighted Article: Cp110 and Cep97, proteins that are normally located at the distal-end of the centriole, appear able to influence the assembly of the centriole cartwheel at the proximal end.
Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ
Summary: Live imaging of the Drosophila intestinal epithelium reveals that stem cells and their terminal progeny exhibit distinct, fate-specific Ca2+ oscillations that are paced independently of each other.
Rac1, the actin cytoskeleton and microtubules are key players in clathrin-independent endophilin-A3-mediated endocytosis
Highlighted Article: Rac1 GTPase, the actin cytoskeleton and microtubules are involved in endophilin-A3-mediated clathrin-independent endocytosis, with a role for myosin 2A, kinesin KIF5B and kinesin-14 family members.
TOOLS AND RESOURCES
Imaging nanoscale nuclear structures with expansion microscopy
Highlighted Article: Expansion microscopy provides quantitative insight into the impact of chromatin modifiers on spatiotemporal organisation of the DNA repair proteins BRCA1, 53BP1 and RAD51 at a resolution of 65–70 nm.
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JCS fast-track option
Have a paper that has been reviewed elsewhere? JCS is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision within one week.
Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Origin and evolution of mitochondrial inner membrane composition
In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.
Resolution in super-resolution microscopy
Super-resolution microscopy (SRM) has emerged as a powerful tool for biological discovery. In this Perspective, Kirti Prakash and colleagues compile expert opinions on crucial, yet often overlooked, aspects of SRM that are essential for maximising its benefits and advancing the field.
