Issues

Summary: We discuss recent findings on the mechanobiology of pluripotent stem cells, highlighting distinctive cellular properties associated with pluripotency and remaining open questions.

Summary: New developments in NMR permit the characterization of sparsely populated states. The application of these methods is illustrated by unraveling pre-nucleation tetramerization of huntingtin.

Summary: Angiomotin isoform 2 (Ap80) interacts with KIF13B and localizes at the base of primary cilia where it recruits PALS1 and regulates ciliary length and signaling.

Summary: CDK activity drives the eukaryotic cell cycle. We show that CDK activity is in surplus, and cells use this surplus to ensure mitotic completion despite CDK inhibition.

Summary: HIV and FIV glycoproteins significantly increase tau release and tau hyperphosphorylation in cultured mouse cortical neurons via activation of cGMP-dependent kinase II.

Summary:Dictyostelium CARMIL-GAP supports phagocytosis and chemotaxis by regulating both capping protein and Rac1.

Summary: MEG8 contributes to endothelial barrier integrity by regulating expression of miRNA-370 and miRNA-494, as well as processing of these miRNAs by interacting with RNA-binding proteins CIRBP and HADHB.

Summary: eIF4G, a eukaryotic translation initiation factor, can facilitate polypeptide exit tunnel maturation and 27S processing correctly during 60S biogenesis.