Summary: We discuss recent findings on the mechanobiology of pluripotent stem cells, highlighting distinctive cellular properties associated with pluripotency and remaining open questions.
NMR spectroscopy, excited states and relevance to problems in cell biology – transient pre-nucleation tetramerization of huntingtin and insights into Huntington's disease
Summary: New developments in NMR permit the characterization of sparsely populated states. The application of these methods is illustrated by unraveling pre-nucleation tetramerization of huntingtin.
Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling
Summary: Angiomotin isoform 2 (Ap80) interacts with KIF13B and localizes at the base of primary cilia where it recruits PALS1 and regulates ciliary length and signaling.
Summary: HIV and FIV glycoproteins significantly increase tau release and tau hyperphosphorylation in cultured mouse cortical neurons via activation of cGMP-dependent kinase II.
The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing
Summary: MEG8 contributes to endothelial barrier integrity by regulating expression of miRNA-370 and miRNA-494, as well as processing of these miRNAs by interacting with RNA-binding proteins CIRBP and HADHB.
Translation initiation factor eIF4G1 modulates assembly of the polypeptide exit tunnel region in yeast ribosome biogenesis
Summary: eIF4G, a eukaryotic translation initiation factor, can facilitate polypeptide exit tunnel maturation and 27S processing correctly during 60S biogenesis.