Issues
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Cover image
Cover Image
Cover: Confocal image showing a chick primary cranial neural crest cell expressing CD63–pHluorin (green). The cell was fixed and stained for HNK-1 (red), F-actin (white) and DNA (DAPI, blue). CD63–pHluorin signal identifies exosome biogenesis taking place within neural crest cells, while overlap of HNK-1 with CD63–pHluorin reveals HNK-1 as a potential neural crest cell exosome marker. See article by C. M. Gustafson et al. (jcs260272).
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RESEARCH HIGHLIGHTS
CELL SCIENTISTS TO WATCH
REVIEWS
Emerging interplay of cytoskeletal architecture, cytomechanics and pluripotency
Summary: We discuss recent findings on the mechanobiology of pluripotent stem cells, highlighting distinctive cellular properties associated with pluripotency and remaining open questions.
NMR spectroscopy, excited states and relevance to problems in cell biology – transient pre-nucleation tetramerization of huntingtin and insights into Huntington's disease
Summary: New developments in NMR permit the characterization of sparsely populated states. The application of these methods is illustrated by unraveling pre-nucleation tetramerization of huntingtin.
SHORT REPORTS
Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling
Summary: Angiomotin isoform 2 (Ap80) interacts with KIF13B and localizes at the base of primary cilia where it recruits PALS1 and regulates ciliary length and signaling.
A CDK activity buffer ensures mitotic completion
Highlighted Article: CDK activity drives the eukaryotic cell cycle. We show that CDK activity is in surplus, and cells use this surplus to ensure mitotic completion despite CDK inhibition.
RESEARCH ARTICLES
Chick cranial neural crest cells release extracellular vesicles that are critical for their migration
Summary: Extracellular vesicles are well defined in cancer, but their normal functions remain less certain. As they migrate, chick neural crest cells deposit migrasomes and release exosomes that are essential for motility.
Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation
Summary: Syntaxin 7 contributes to invadopodia formation and associated activity by forming multiple SNARE complexes that support the delivery of essential cargo to invadopodial sites.
MKLP2 functions in early mitosis to ensure proper chromosome congression
Summary: Inhibition of the motor protein MKLP2 results in a mitotic arrest characterized by the presence of pole-proximal chromosomes with unstable syntelic kinetochore–microtubule attachments.
HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation
Highlighted Article: HIV and FIV glycoproteins significantly increase tau release and tau hyperphosphorylation in cultured mouse cortical neurons via activation of cGMP-dependent kinase II.
Dual regulation of the actin cytoskeleton by CARMIL-GAP
Highlighted Article: Dictyostelium CARMIL-GAP supports phagocytosis and chemotaxis by regulating both capping protein and Rac1.
The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing
Summary: MEG8 contributes to endothelial barrier integrity by regulating expression of miRNA-370 and miRNA-494, as well as processing of these miRNAs by interacting with RNA-binding proteins CIRBP and HADHB.
Translation initiation factor eIF4G1 modulates assembly of the polypeptide exit tunnel region in yeast ribosome biogenesis
Summary: eIF4G, a eukaryotic translation initiation factor, can facilitate polypeptide exit tunnel maturation and 27S processing correctly during 60S biogenesis.
FIRST PERSON
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'

Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Early-bird deadline is 19 January 2024.
FocalPlane image competition winner: Rebecca Simkin

We are delighted to announce that the winner of the 2023 FocalPlane image competition is Rebecca Simkin. Rebecca’s image, ‘Neuromuscular junctions’, depicts four NMJs in a lumbrical muscle, located in the hind paw of a wildtype mouse. Read the full interview here.
Reasons to submit to Journal of Cell Science

There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
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