Issues
REVIEWS
Emerging interplay of cytoskeletal architecture, cytomechanics and pluripotency
Summary: We discuss recent findings on the mechanobiology of pluripotent stem cells, highlighting distinctive cellular properties associated with pluripotency and remaining open questions.
NMR spectroscopy, excited states and relevance to problems in cell biology – transient pre-nucleation tetramerization of huntingtin and insights into Huntington's disease
Summary: New developments in NMR permit the characterization of sparsely populated states. The application of these methods is illustrated by unraveling pre-nucleation tetramerization of huntingtin.
SHORT REPORTS
Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling
Summary: Angiomotin isoform 2 (Ap80) interacts with KIF13B and localizes at the base of primary cilia where it recruits PALS1 and regulates ciliary length and signaling.
A CDK activity buffer ensures mitotic completion
Summary: CDK activity drives the eukaryotic cell cycle. We show that CDK activity is in surplus, and cells use this surplus to ensure mitotic completion despite CDK inhibition.
RESEARCH ARTICLES
HIV and FIV glycoproteins increase cellular tau pathology via cGMP-dependent kinase II activation
Summary: HIV and FIV glycoproteins significantly increase tau release and tau hyperphosphorylation in cultured mouse cortical neurons via activation of cGMP-dependent kinase II.
Dual regulation of the actin cytoskeleton by CARMIL-GAP
Summary:Dictyostelium CARMIL-GAP supports phagocytosis and chemotaxis by regulating both capping protein and Rac1.
The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and -494 processing
Summary: MEG8 contributes to endothelial barrier integrity by regulating expression of miRNA-370 and miRNA-494, as well as processing of these miRNAs by interacting with RNA-binding proteins CIRBP and HADHB.
Translation initiation factor eIF4G1 modulates assembly of the polypeptide exit tunnel region in yeast ribosome biogenesis
Summary: eIF4G, a eukaryotic translation initiation factor, can facilitate polypeptide exit tunnel maturation and 27S processing correctly during 60S biogenesis.
FIRST PERSON
2021 JCS Prize winner announced
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We are pleased to announce that the winner of the 2021 JCS Prize is Lee Dolat for his paper entitled ‘An endometrial organoid model of interactions between Chlamydia and epithelial and immune cells’.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Cell scientist to watch: Christian Münch
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Journal of Cell Science interviewed Christian Münch, who established his independent research group in 2016 at Goethe University Frankfurt. His lab studies cellular stress responses to mitochondrial protein misfolding, infection and disease, as well as developing proteomics methods.
Essay series: Equity, diversity and inclusion in cell biology
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The JCS Essay Series is an initiative to help showcase and provide a platform for voices in the field of cell biology. The first topic we covered was 'Equity, diversity and inclusion in cell biology', and the winning and runner up essays are now available to read.
FocalPlane Network launched
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We are excited to announce the launch of the FocalPlane Network, an international directory of microscopists. The idea behind the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.