Issues

Summary: This Review describes current knowledge on the major role of the Golgi apparatus, the central organelle of the secretory pathway, in the production and maintenance of the extracellular matrix.

Summary: Extracellular vesicles, which are natural nanoparticles released from all cells, hold great promise to transform future medicine and enable truly personalised treatments.

Summary: Collagen XI, a minor fibrillar collagen, is expressed in mouse corneal stroma during early development and following injury in adults to regulate collagen fibrillogenesis.

Summary: The TAZ protein, an effector of Hippo signaling that phase separates into biomolecular condensates in the nucleus, is shown to hold myogenic cells in an undifferentiated state by repressing a muscle-specific transcription complex.

Highlighted Article: Cytoplasmic exploration of human, mouse and frog early oocytes showed that primordial oocytes have active organelles, and unlike human and frog, mouse oocytes do not contain a Balbiani body.

Summary: Mitochondria and peroxisomes respond to endoplasmic reticulum stress to help promote cell survival by reducing accumulation of reactive oxygen species.

Summary: Hyperglycemia experienced during embryonic development in zebrafish has deleterious effects on photoreceptor differentiation that persist even after a return to normoglycemic conditions.

Summary:Salmonella replicates in host cells in a membrane compartment that it shapes with the help of host proteins; a molecular motor of the kinesin-3 family is involved in this process.

Highlighted Article: In clathrin-independent endocytosis, γ-taxilin negatively regulates sorting of Hook1-mediated cargo proteins into recycling endosomes by interfering with interactions between Hook1 and the cargo proteins.

Summary: Syntaxin-4 knockout reduces insulin-stimulated glucose transport, depletes levels of cellular GLUT4 and inhibits secretion of adiponectin but only modestly affects the translocation capacity of the cells.

Highlighted Article: Smaug1 bodies contain mRNAs for mitochondrial enzymes and defective Smaug1 body formation impairs mitochondrial function. Adding to this interplay, Smaug1 bodies respond to changes in oxidative phosphorylation involving AMPK.

Summary: The direct evaluation of kinetochore associations on intact chromosomes demonstrates meiosis I-specific sister kinetochore association and its dependency on meiotic cohesin in fission yeast.

Highlighted Article: Septin 9 isoform 1 has a unique motif targeting septin octamers to microtubules. Modulation of this targeting affects microtubule stability and actomyosin fiber distribution and tension in cells.

Summary: We demonstrate a novel mode of insulin signalling regulation in which the amount of insulin receptor on the cell surface is maintained at moderate levels to sustain activation of insulin signalling.

Summary: Knockdown of minor spliceosome component U6atac in cardiomyocytes reveals that expression of the Na⁺ channel Scn5a and the L-type Ca²⁺ channel Cacna1c critically depend on minor intron splicing.

Summary: Identification of AMBRA1 as a new regulator of dsRNA- or virus-induced apoptosis, and characterization of its role in interacting with and stabilizing a key adaptor (MAVS) in the apoptosis pathway.