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EDITORIAL

FIRST PERSON

STICKY WICKET

JCS PRIZE

CELL SCIENTISTS TO WATCH

REVIEWS

Summary: This Review discusses the role of actin-binding protein profilin1 in major diseaeses with cardiovascular associations including atherosclerosis, hypertension and diabetes.

SUBJECT COLLECTION: IMAGING

Summary: This Review describes lifetime imaging methodologies that are important for multiparameter 3D imaging of cells, tissues and small animals, with brief discussion of the underlying biosensing technologies.

Summary: Studies have uncovered multiple roles for SLK in various biological processes. We review the complex functions and regulation patterns of SLK in development and disease, that make it a potential therapeutic target.

SHORT REPORTS

Summary: The plasma membrane-associated Zdhhc5 enzyme enhances excitatory synapse formation in vitro and in vivo through motifs at its C-terminal domain.

Summary: An ancient glaucophyte c6-like cytochrome related to cyanobacterial cytochromes c6BC and higher plant c6A is imported into muroplast thylakoids via the Sec pathway.

RESEARCH ARTICLES

Summary: In mast cells, the scaffold protein RACK1 acts as a key hub in the arrangement of the actin cytoskeleton, impacting both store-operated Ca2+ entry and regulated secretion.

Summary: Reduced protein synthesis is required for stem cell functions. Here, we delineate a complex interplay of polyamines and mRNA translation that determines hair follicle stem cell fate decisions.

Summary: Mutagenic, expression and histological analyses reveal an essential role for miR-34b/c and miR-449 in multiciliogenesis in efferent ductules of the male reproductive tract by regulating cell cycle exit.

Summary: At the Drosophila glutamatergic neuromuscular junction (NMJ), a secreted, Ca2+-binding C-type lectin (Lectin-galC1) modulates synaptic transmission strength and resiliency by regulating synaptic vesicle cycle dynamics.

Summary: In addition to regulating peroxisome synthesis, the methanol sensor Wsc1 also regulates pexophagy through a downstream MAPK pathway that mediates phospho-regulation of the pexophagy receptor protein Atg30.

Summary: Fusion of monocytes to become bone-resorbing osteoclasts is limited by an SNX10-dependent cell-autonomous mechanism. Loss of SNX10 function deregulates fusion and generates giant inactive osteoclasts.

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