Issues
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Cover image
Cover Image
Cover: APP endocytosis increases in aged primary neurons, as visualised using widefield microscopy. The pseudo-coloured image shows numerous APP-containing endosomes in aged neurons labelled by a 10-minute pulse of anti-APP antibody, with surface APP in blue and endocytosed APP in green and yellow (mpl-viridis lookup table). As neurons age, synaptic density declines and β-amyloid accumulates intraneuronally. New evidence indicates that neuronal aging contributes to Alzheimer’s disease by upregulating APP endocytosis, which increases β-amyloid production, leading to synapse loss. See article by T. Burrinha et al. (jcs255752).
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RESEARCH HIGHLIGHTS
EDITORIAL
JCS PRIZE
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEWS
The role of profilin-1 in cardiovascular diseases
Summary: This Review discusses the role of actin-binding protein profilin1 in major diseaeses with cardiovascular associations including atherosclerosis, hypertension and diabetes.
Luminescence lifetime imaging of three-dimensional biological objects
Summary: This Review describes lifetime imaging methodologies that are important for multiparameter 3D imaging of cells, tissues and small animals, with brief discussion of the underlying biosensing technologies.
The Ste20-like kinase – a Jack of all trades?
Summary: Studies have uncovered multiple roles for SLK in various biological processes. We review the complex functions and regulation patterns of SLK in development and disease, that make it a potential therapeutic target.
SHORT REPORTS
Regulation of hippocampal excitatory synapses by the Zdhhc5 palmitoyl acyltransferase
Highlighted Article: The plasma membrane-associated Zdhhc5 enzyme enhances excitatory synapse formation in vitro and in vivo through motifs at its C-terminal domain.
An ancient glaucophyte c6-like cytochrome related to higher plant cytochrome c6A is imported into muroplasts
Summary: An ancient glaucophyte c6-like cytochrome related to cyanobacterial cytochromes c6BC and higher plant c6A is imported into muroplast thylakoids via the Sec pathway.
RESEARCH ARTICLES
Non-canonical argonaute loading of extracellular vesicle-derived exogenous single-stranded miRNA in recipient cells
Summary: Loading of extracellular vesicle-derived miRNAs on recipient cell Ago2 occurs on endosomal membranes and is dependent on endosomal maturation and pH-driven cytosolic release of internalized miRNAs.
Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss
Highlighted Article: Identification of the upregulation of APP endocytosis as a mechanism used by normal neuronal aging to increase intracellular Aβ, contributing to aging-dependent synapse loss.
WNT-responsive SUMOylation of ZIC5 promotes murine neural crest cell development, having multiple effects on transcription
Highlighted Article: ZIC5 is SUMOylated in response to WNT signalling. This increases ZIC5 transcriptional activation but reduces ZIC5/TCF co-repression to promote neural crest specification throughout.
RACK1 plays a critical role in mast cell secretion and Ca2+ mobilization by modulating F-actin dynamics
Summary: In mast cells, the scaffold protein RACK1 acts as a key hub in the arrangement of the actin cytoskeleton, impacting both store-operated Ca2+ entry and regulated secretion.
N1-acetylspermidine is a determinant of hair follicle stem cell fate
Summary: Reduced protein synthesis is required for stem cell functions. Here, we delineate a complex interplay of polyamines and mRNA translation that determines hair follicle stem cell fate decisions.
Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit
Summary: Mutagenic, expression and histological analyses reveal an essential role for miR-34b/c and miR-449 in multiciliogenesis in efferent ductules of the male reproductive tract by regulating cell cycle exit.
Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement
Highlighted Article: At the Drosophila glutamatergic neuromuscular junction (NMJ), a secreted, Ca2+-binding C-type lectin (Lectin-galC1) modulates synaptic transmission strength and resiliency by regulating synaptic vesicle cycle dynamics.
The methanol sensor Wsc1 and MAPK Mpk1 suppress degradation of methanol-induced peroxisomes in methylotrophic yeast
Summary: In addition to regulating peroxisome synthesis, the methanol sensor Wsc1 also regulates pexophagy through a downstream MAPK pathway that mediates phospho-regulation of the pexophagy receptor protein Atg30.
An SNX10-dependent mechanism downregulates fusion between mature osteoclasts
Summary: Fusion of monocytes to become bone-resorbing osteoclasts is limited by an SNX10-dependent cell-autonomous mechanism. Loss of SNX10 function deregulates fusion and generates giant inactive osteoclasts.
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Extended submission deadline: 31 March 2025.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Journal of Cell Science’s journey and explore the history of each of our sister journals: Development, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Introducing our new Associate Editors
In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
Diversity of microtubule arrays in animal cells at a glance
In this Cell Science at a Glance article, Emma van Grinsven and Anna Akhmanova provide an overview of the diverse microtubule arrays present in differentiated animal cells and discuss how these arrays form and function.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
