CELL SCIENTISTS TO WATCH
Summary: This Review describes lifetime imaging methodologies that are important for multiparameter 3D imaging of cells, tissues and small animals, with brief discussion of the underlying biosensing technologies.
Summary: Studies have uncovered multiple roles for SLK in various biological processes. We review the complex functions and regulation patterns of SLK in development and disease, that make it a potential therapeutic target.
Summary: The plasma membrane-associated Zdhhc5 enzyme enhances excitatory synapse formation in vitro and in vivo through motifs at its C-terminal domain.
An ancient glaucophyte c6-like cytochrome related to higher plant cytochrome c6A is imported into muroplasts
Summary: An ancient glaucophyte c6-like cytochrome related to cyanobacterial cytochromes c6BC and higher plant c6A is imported into muroplast thylakoids via the Sec pathway.
RACK1 plays a critical role in mast cell secretion and Ca2+ mobilization by modulating F-actin dynamics
Summary: In mast cells, the scaffold protein RACK1 acts as a key hub in the arrangement of the actin cytoskeleton, impacting both store-operated Ca2+ entry and regulated secretion.
Summary: Reduced protein synthesis is required for stem cell functions. Here, we delineate a complex interplay of polyamines and mRNA translation that determines hair follicle stem cell fate decisions.
Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit
Summary: Mutagenic, expression and histological analyses reveal an essential role for miR-34b/c and miR-449 in multiciliogenesis in efferent ductules of the male reproductive tract by regulating cell cycle exit.
Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement
Summary: At the Drosophila glutamatergic neuromuscular junction (NMJ), a secreted, Ca2+-binding C-type lectin (Lectin-galC1) modulates synaptic transmission strength and resiliency by regulating synaptic vesicle cycle dynamics.
The methanol sensor Wsc1 and MAPK Mpk1 suppress degradation of methanol-induced peroxisomes in methylotrophic yeast
Summary: In addition to regulating peroxisome synthesis, the methanol sensor Wsc1 also regulates pexophagy through a downstream MAPK pathway that mediates phospho-regulation of the pexophagy receptor protein Atg30.
Summary: Fusion of monocytes to become bone-resorbing osteoclasts is limited by an SNX10-dependent cell-autonomous mechanism. Loss of SNX10 function deregulates fusion and generates giant inactive osteoclasts.