Issues

Summary: This Review highlights recent advances and questions remaining in the field of cytokinesis, and how gene editing tools will facilitate significant advances in the field.

Summary: This Review discusses the ‘nuclear calcium hypothesis’ in the context of human brain function, the role of nuclear Ca²⁺ in controlling diverse forms of neuroadaptation and neuroprotection, and its dysregulation in disease.

Summary: In this Review, we present an update of recent progress in obtaining kindlin structures, and the implication for integrin activation based on formation of kindlin oligomerization as well as the regulation of this process.

Summary:Drosophila Dock likely functions downstream of WASp and the Arp2/3 complex to regulate the size and stability of the germline ring canals in the developing egg chamber.

Highlighted Article: A crucial step in endosomal maturation is the exchange of Rab5 with Rab7a, and we show that this two-phase exchange is finalized by the formation of Rab5-positive early endosomes.

Summary: Fibronectin and galectin-8 have dramatically different effects on cell spreading and focal adhesion formation; however, when mixed, they synergize in stimulating filopodia formation.

Summary: The ribosome-associated quality control factor ZNF598, which senses ribosome collisions, is a host factor necessary for vaccinia viral protein synthesis.

Summary: The autophagy proteins TMEM41B and VMP1 belong to the DedA superfamily, whose members are predicted to have ion-coupled transporter-like structures containing two facing reentrant loops.

Highlighted Article: Ultrastructural analysis of T cell migration across the blood–brain barrier (BBB) under physiological flow identifies BBB tricellular junctions as sites of T cell diapedesis.

Highlighted Article: The inhibitor SMIFH2 inhibits a variety of myosins almost as efficiently as formins, its designated targets.

Summary: NRP1 can regulate AKR1B10 expression, and AKR1B10 interacts with and inhibits the nuclear importation of GAPDH to repress autophagy upon glucose starvation.

Summary: The α-arrestin ARRDC3 is a multi-functional tumor suppressor that distinctly regulates GPCR trafficking and TAZ-dependent Hippo signaling in metastatic triple negative breast cancer.

Summary: Tyrosine sulfation and O-glycosylation in the N-terminus of the chemoattractant receptor GPR15 oppositely regulate the binding of its ligand GPR15L and receptor signaling.

Highlighted Article: Bax-mediated translocation of Cdk1–cyclin B to the mitochondrion signals cell death and is the cytoplasmic signal that connects mitotic cell cycle arrest to apoptosis.

Summary: A robust and flexible approach to understand tissue-specific gene functions in vivo is established that allows efficient gene disruption, gene-specific rescue and biosensor imaging in the knockout background.