Issues
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Cover image
Cover Image
Cover: A confocal image of the infundibulum region of the mouse oviduct epithelium. Adult oviduct was stained for ZO1 (green), γ-tubulin (green) and Odf2 (red), and with Hoechst (blue). Two folds can be found in the image. The multiciliated cells, with around 150 basal bodies, are visualized with γ-tubulin and Odf2 as small dots, and secreted cells are seen with with large two dots of γ-tubulin. In the multiciliated cells, basal bodies are aligned, and cilia make directional movements, which are coordinated within each cell, as well as between cells, to enable transportation of eggs from ovary to the uterus. See article by F. M. Usami et al. (jcs257006).
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RESEARCH HIGHLIGHTS
STICKY WICKETS
FIRST PERSON
REVIEWS
Tensins – emerging insights into their domain functions, biological roles and disease relevance
Summary: This Review discusses current understanding on the domain functions and biological roles of tensins in cells and mice as well as their contributions to disease development.
Innate immune receptor clustering and its role in immune regulation
Summary: This Review discusses the formation and mechanisms of innate immune receptor clustering and how nanotechnologies have contributed to understanding the regulatory role of receptor clustering in innate immune cells.
Cytoskeletal mechanics and dynamics in the Drosophila syncytial embryo
Summary: This Review discusses the dynamics and function of F-actin and microtubules in syncytial Drosophila embryos with respect to tissue mechanics and self-organization processes.
SHORT REPORT
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
Summary: Ipomoeassin-F blocks the Sec61-dependent translocation of SARS-CoV-2 proteins into and across the endoplasmic reticulum, highlighting the potential of Sec61 inhibitors as antiviral agents.
RESEARCH ARTICLES
Aberrant cytoplasmic localization of ARID1B activates ERK signaling and promotes oncogenesis
Highlighted Article: When ARID1B, an important component of the SWI/SNF chromatin remodeling complex, localizes to the cytoplasm, it exhibits a novel gain of oncogenic function.
Vacuolar protein Tag1 and Atg1–Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae
Summary: Genome-wide screening identified a novel vacuolar protein, Tag1, responsible for termination of autophagy in yeast. Tag1 regulates autophagy termination via re-phosphorylation of Atg13 mediated by the Atg1 kinase.
Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function
Summary: Adenine nucleotide translocase protects Dictyostelium and human airway cells from cigarette smoke, promoting mitochondrial respiration, airway surface hydration and facilitating ciliary function.
Fibronectin Extra Domains tune cellular responses and confer topographically distinct features to fibril networks
Summary: Fibronectin, a major building block of tissues and organs, tunes fibroblast behavior and matrix architecture through the presence of alternatively spliced extra domains.
Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multi-ciliated cells
Summary: CELSR1 and CAMSAP3 are responsible for intercellular and intracellular basal body orientation, and their cooperation is critical for generating functional multi-ciliated epithelium in the mouse oviduct.
Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy
Highlighted Article: Live imaging of mitophagy reporter zebrafish shows mitophagy occurs via a piece-by-piece mechanism in vivo. Hypoxia induces mitophagy in muscle in a bnip3-dependent but pink1-independent manner.
Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex in fission yeast
Summary: We report the first identification of a nuclear localization signal for the meiotic recombination-promoting complex, the linear elements of fission yeast, related to the synaptonemal complex of other species.
The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype
Summary: Downregulation of icIL-1RA1 at the early stages of carcinogenesis can enable the development of a premature and deregulated senescence-associated secretory phenotype.
Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death
Summary: Prostate cancer cells have different sensitivities to fluid forces that alter their resistance to elevated blood flow-level fluid shear stress.
Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation
Summary: TPX2 regulates astral microtubules and spindle orientation. TPX2 is locally activated via the Golgi protein GM130 by sequestering importin α from TPX2, a process enabled by importin α phosphorylation at S62.
SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72
Summary: Expression level modulation of the core paraspeckle protein SFPQ regulates sense and antisense RNA foci and dipeptide repeat protein accumulation in the C9orf72 mutation; SFPQ could be a therapeutic target in C9orf72 ALS and FTD.
The 5-HT4 receptor interacts with adhesion molecule L1 to modulate morphogenic signaling in neurons
Highlighted Article: Physical interaction between serotonin receptor 5-HT4 and adhesion molecule L1 facilitates ERK activation and modulates cofilin activity, regulating receptor-dependent maturation of synaptic connections.
Distinct epithelial-to-mesenchymal transitions induced by PIK3CAH1047R and PIK3CB
Summary:PIK3CAH1047R or PIK3CB expression induce distinct transformed phenotypes in MCF-10A cells; the transformed phenotype resulting from PIK3CB amplification depends on its unique interaction with Rac1.
Call for papers - Cilia and Flagella: from Basic Biology to Disease
We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The deadline for abstract submission and early-bird registration is 17 January 2025.
Fantastic proteins and where to find them – histones, in the nucleus and beyond
In this Review, Johanna Grinat and colleagues provide an evolutionary perspective of histones, nuclear chromatin and extracellular chromatin biology, describing the known extranuclear and extracellular functions of histones.
JCS-FocalPlane Training Grants
Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).
How to reduce your lab's carbon footprint
All stakeholders – from those working in the lab to those providing funding and infrastructure – have an important role to play to becoming more sustainable. In this Essay, Julie Welburn discusses what lab users can collectively do to transform biomedical research into a discipline that is significantly and positively sustainable.
