Summary: This Review discusses current understanding on the domain functions and biological roles of tensins in cells and mice as well as their contributions to disease development.
Summary: This Review discusses the formation and mechanisms of innate immune receptor clustering and how nanotechnologies have contributed to understanding the regulatory role of receptor clustering in innate immune cells.
Summary: This Review discusses the dynamics and function of F-actin and microtubules in syncytial Drosophila embryos with respect to tissue mechanics and self-organization processes.
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor
Summary: Ipomoeassin-F blocks the Sec61-dependent translocation of SARS-CoV-2 proteins into and across the endoplasmic reticulum, highlighting the potential of Sec61 inhibitors as antiviral agents.
Highlighted Article: When ARID1B, an important component of the SWI/SNF chromatin remodeling complex, localizes to the cytoplasm, it exhibits a novel gain of oncogenic function.
Vacuolar protein Tag1 and Atg1–Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae
Summary: Genome-wide screening identified a novel vacuolar protein, Tag1, responsible for termination of autophagy in yeast. Tag1 regulates autophagy termination via re-phosphorylation of Atg13 mediated by the Atg1 kinase.
Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function
Summary: Adenine nucleotide translocase protects Dictyostelium and human airway cells from cigarette smoke, promoting mitochondrial respiration, airway surface hydration and facilitating ciliary function.
Fibronectin Extra Domains tune cellular responses and confer topographically distinct features to fibril networks
Summary: Fibronectin, a major building block of tissues and organs, tunes fibroblast behavior and matrix architecture through the presence of alternatively spliced extra domains.
Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multi-ciliated cells
Summary: CELSR1 and CAMSAP3 are responsible for intercellular and intracellular basal body orientation, and their cooperation is critical for generating functional multi-ciliated epithelium in the mouse oviduct.
Quantitative intravital imaging in zebrafish reveals in vivo dynamics of physiological-stress-induced mitophagy
Highlighted Article: Live imaging of mitophagy reporter zebrafish shows mitophagy occurs via a piece-by-piece mechanism in vivo. Hypoxia induces mitophagy in muscle in a bnip3-dependent but pink1-independent manner.
Activation of meiotic recombination by nuclear import of the DNA break hotspot-determining complex in fission yeast
Summary: We report the first identification of a nuclear localization signal for the meiotic recombination-promoting complex, the linear elements of fission yeast, related to the synaptonemal complex of other species.
The role of icIL-1RA in keratinocyte senescence and development of the senescence-associated secretory phenotype
Summary: Downregulation of icIL-1RA1 at the early stages of carcinogenesis can enable the development of a premature and deregulated senescence-associated secretory phenotype.
Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death
Summary: Prostate cancer cells have different sensitivities to fluid forces that alter their resistance to elevated blood flow-level fluid shear stress.
Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation
Summary: TPX2 regulates astral microtubules and spindle orientation. TPX2 is locally activated via the Golgi protein GM130 by sequestering importin α from TPX2, a process enabled by importin α phosphorylation at S62.
SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72
Summary: Expression level modulation of the core paraspeckle protein SFPQ regulates sense and antisense RNA foci and dipeptide repeat protein accumulation in the C9orf72 mutation; SFPQ could be a therapeutic target in C9orf72 ALS and FTD.
Highlighted Article: Physical interaction between serotonin receptor 5-HT4 and adhesion molecule L1 facilitates ERK activation and modulates cofilin activity, regulating receptor-dependent maturation of synaptic connections.
Summary:PIK3CAH1047R or PIK3CB expression induce distinct transformed phenotypes in MCF-10A cells; the transformed phenotype resulting from PIK3CB amplification depends on its unique interaction with Rac1.