Issues
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Cover image
Cover Image
Cover: High-resolution structured illumination microscopy image of wild-type macrophages isolated from Drosophila prepupae and stained for F-actin. See article by A. Hirschhäuser et al. (jcs258891).
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RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Cargo sorting at the trans-Golgi network at a glance
Summary: An illustrated framework of the conceptual mainstays of Golgi sorting and export.
RESEARCH ARTICLES
Nup93 and CTCF modulate spatiotemporal dynamics and function of the HOXA gene locus during differentiation
Summary: Nucleoporin Nup93 has a novel and complementary role with the chromatin organizer CTCF in differentially regulating the organization and function of the HOXA gene locus during differentiation.
CK1α protects WAVE from degradation to regulate cell shape and motility in the immune response
Summary: We identified CK1α as a novel regulator of WAVE controlling cell shape and motility in immune response. Basal phosphorylation of WAVE by CK1α protects it from premature proteasomal degradation.
α-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization
Summary: We show that α-actinin-4 drives cancer invasiveness by regulating expression of myosin IIB, which is required for nuclear squeezing, and modulation of adhesion turnover via retention of myosin IIA at the cell periphery.
Precursor types predict the stability of neuronal branches
Summary: Branches of neurons differ in stability. We describe evidence that this stability is already defined during formation, suggesting separate branch maintenance modes initiated by distinct branch precursors.
Plekhh1, a partner of myosin 1 and an effector of EphB2, controls the cortical actin network during cell repulsion
Summary: Plekhh1 is an effector of EphB2 receptors and a partner of myosin 1 proteins. It contributes to cell repulsion by regulating the architecture of the cortical actin network.
The Hsp70–Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap
Highlighted Article: We show how the Hsp70–Bag3 module regulates the Hippo pathway. This regulatory mechanism involves control of nuclear translocation of the transcription factor Yap.
The microtubule-associated protein She1 coordinates directional spindle positioning by spatially restricting dynein activity
Highlighted Article: The astral microtubule-bound population of She1 attenuates the initiation of dynein-mediated spindle movement events in a compartment-specific manner, thus promoting directionally biased transport events in budding yeast.
Nuclear import of BCL11B is mediated by a classical nuclear localization signal and not the Krüppel-like zinc fingers
Summary: The BCL11B transcription factor migrates to the nucleus using the classical import pathway and a unique, previously unidentified and conserved NLS located at a distance from its DNA-binding Krüppel-like zinc finger motifs.
Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans
Highlighted Article: Phosphorylation of the essential centromere protein KNL-2 is required for mitotic chromosome condensation, but not for the role of KNL-2 in centromere maintenance and kinetochore formation.
2021 JCS Prize winner announced
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We are pleased to announce that the winner of the 2021 JCS Prize is Lee Dolat for his paper entitled ‘An endometrial organoid model of interactions between Chlamydia and epithelial and immune cells’.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Cell scientist to watch: Christian Münch
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Journal of Cell Science interviewed Christian Münch, who established his independent research group in 2016 at Goethe University Frankfurt. His lab studies cellular stress responses to mitochondrial protein misfolding, infection and disease, as well as developing proteomics methods.
Essay series: Equity, diversity and inclusion in cell biology
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The JCS Essay Series is an initiative to help showcase and provide a platform for voices in the field of cell biology. The first topic we covered was 'Equity, diversity and inclusion in cell biology', and the winning and runner up essays are now available to read.
FocalPlane Network launched
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We are excited to announce the launch of the FocalPlane Network, an international directory of microscopists. The idea behind the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.