Issues

Summary: An illustrated framework of the conceptual mainstays of Golgi sorting and export.

Summary: Nucleoporin Nup93 has a novel and complementary role with the chromatin organizer CTCF in differentially regulating the organization and function of the HOXA gene locus during differentiation.

Summary: We identified CK1α as a novel regulator of WAVE controlling cell shape and motility in immune response. Basal phosphorylation of WAVE by CK1α protects it from premature proteasomal degradation.

Summary: We show that α-actinin-4 drives cancer invasiveness by regulating expression of myosin IIB, which is required for nuclear squeezing, and modulation of adhesion turnover via retention of myosin IIA at the cell periphery.

Summary: Branches of neurons differ in stability. We describe evidence that this stability is already defined during formation, suggesting separate branch maintenance modes initiated by distinct branch precursors.

Summary: Plekhh1 is an effector of EphB2 receptors and a partner of myosin 1 proteins. It contributes to cell repulsion by regulating the architecture of the cortical actin network.

Highlighted Article: We show how the Hsp70–Bag3 module regulates the Hippo pathway. This regulatory mechanism involves control of nuclear translocation of the transcription factor Yap.

Highlighted Article: The astral microtubule-bound population of She1 attenuates the initiation of dynein-mediated spindle movement events in a compartment-specific manner, thus promoting directionally biased transport events in budding yeast.

Summary: The BCL11B transcription factor migrates to the nucleus using the classical import pathway and a unique, previously unidentified and conserved NLS located at a distance from its DNA-binding Krüppel-like zinc finger motifs.

Highlighted Article: Phosphorylation of the essential centromere protein KNL-2 is required for mitotic chromosome condensation, but not for the role of KNL-2 in centromere maintenance and kinetochore formation.