CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: An overview of our current understanding of cargo transport through the NPC, from the basic transport signals and machinery to more emerging aspects, all from a cargo perspective.
Summary: A discussion of the diverse cell biological roles of autophagy that promote and suppress metastatic progression in cancer.
Local translation in perisynaptic and perivascular astrocytic processes – a means to ensure astrocyte molecular and functional polarity?
Summary: This Review summarizes our current knowledge about mRNA distribution and local translation in astrocytes.
Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression
Highlighted Article: Double-knockout of CDC14A and CDC14B in human RPE1 cells reveals that there is no redundancy masking a function in mitotic progression; instead, these phosphatases are involved in processes such as ciliogenesis.
Highlighted Article: APC control of intestinal epithelia structure and function is regulated through three independent effector pathways specifying cell proliferation, epithelial morphology and intracellular organisation.
Summary: PLEKHG4B, a Rho-guanine nucleotide exchange factor, is required for actin cytoskeletal remodeling during epithelial cell–cell junction maturation through regulating myosin activity.
Summary: Lysosomal agents uncouple ER Ca2+-release from store-operated Ca2+ entry, predominantly by inhibiting Stim1 oligomerization and its activation of Orai.
Highlighted Article: Hydrostatic pressure promotes chondrocyte quiescence and immature chondrocyte state through reducing the amount of H3K9me3-marked heterochromatin.
Matrix stiffness regulates α-TAT1-mediated acetylation of α-tubulin and promotes silica-induced epithelial–mesenchymal transition via DNA damage
Summary: This study provides insight into how the cell cycle is regulated during the EMT and why a decrease in α-TAT1 and Ac-α-Tub promotes silicosis fibrosis.
Sequestration of the PKC ortholog Pck2 in stress granules as a feedback mechanism of MAPK signaling in fission yeast
Summary: Pmk1 regulates Pck2 recruitment into stress granules (SGs) upon heat stress, which intercepts MAPK signaling activation, indicating that SGs sequester active Pck2 in a feedback mechanism.
Summary: A novel mechanism revealing the role of the actin cytoskeleton in Wnt signalosome assembly, defining Daam2 as a hub for coordinating the action of PIP5K and the Rho GTPase Rac1.
Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage
Summary: OptoSRC allows control of SRC signaling with high spatio-temporal resolution, revealing new functions of SRC oligomers and key features of SRC signal encoding and decision-making activity.
Summary: The single TNF-R homologue in the cnidarian Hydra is related to human EDAR, involved in cell differentiation and not part of a FADD-dependent death pathway.
A glucose-starvation response governs endocytic trafficking and eisosomal retention of surface cargoes in budding yeast
Summary: Endocytosis of many cell surface proteins is triggered following glucose starvation, with recovery from starvation mediated by a small fraction of nutrient transporters preserved at the surface in eisosomes.
A putative stem-loop structure in Drosophila crumbs is required for mRNA localisation in epithelia and germline cells
Highlighted Article: Deletion of the localisation element disrupts asymmetric crb mRNA localisation in epithelia without affecting Crb protein localisation, and impairs crb mRNA transport to the oocyte.
SetDB1 and Su(var)3-9 play non-overlapping roles in somatic cell chromosomes of Drosophila melanogaster
Summary: A genome-wide analysis of SetDB1 was matched to the profile of Su(var)3-9 in order to decipher the functional specialization of these two H3K9-specific Drosophila methyltransferases.
Summary: A novel fusion machinery comprising EFA6A, Arf6 and Arl13B controls the coordinated fusion of ciliary vesicles docked at the distal appendages of the mother centriole.