Issues

Summary: We discuss latest progresses on prion protein and prion disease and highlight the emerging prionoid concept as well as the recent advances on the diagnosis and therapeutics of prion disease.

Summary: A summary of recent advancements in live-cell imaging using high-speed atomic force microscopy, with a special emphasis on its application to morphological dynamics of the plasma membrane during endocytosis.

Summary: In addition to its well-known regulation by nutrients and hormones, autophagy occupies a central position in the integration of mechanical forces to contribute to tissue homeostasis.

Highlighted Article: Transient SUMOylation of RepoMan controls the recruitment of lamin A to telophase chromosomes, lamin A dephosphorylation and nuclear lamina formation.

Summary: TANGO1 is required to maintain the fundamental organization of the early secretory pathway in mammalian cells to support secretion of a diverse range of newly synthesized cargo proteins.

Summary: During synaptic plasticity to enhance synaptic strength, phosphorylation of AMPA receptor subunit GluA1 at serine 845 reduces receptor internalization by inhibiting interactions with endocytic proteins.

Summary: We report a novel, non-canonical role for ADAR1 as a negative regulator of stress granules that has implications for the role of ADAR1 in the antiviral response.

Summary: In S2 cells, the phase-separated Sec bodies form upon the combined activation of salt-inducible kinases, IRE1 and PERK.

Highlighted Article: Downregulation of the single C. elegans lamin gene increases animal size and fat content specifically in dietary restricted animals. The lamin protein acts in the mTOR pathway to regulate these phenotypes.

Highlighted Article: Liquid–liquid phase separation of oncogenic fusion proteins could be a potential mechanism for aberrant transcriptional activation.

Highlighted Article: Tagged endogenous C. elegans MPK-1 shows activation-dependent cytosol-to-nuclear translocation. This tool provides novel insights into MPK-1 localization compared with other markers of in vivo ERK activation.

Summary: Contractile signaling promotes stabilization of E-cadherin to enforce orderly epithelial migration.

Summary: Vascular leak in response to histamine, thrombin and VEGF can be counteracted by AMPK phosphorylating cingulin at its head domain. Consequential binding of GEF-H1 to tight junctions protects vascular barrier function.

Summary: The dT-2xrGBD location-based Rho biosensor relocalizes more efficiently than other sensors of this type, and this sensor enables the observation of endogenous Rho activity in cultured cells.