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RESEARCH HIGHLIGHTS

STICKY WICKET

FIRST PERSON

CELL SCIENTISTS TO WATCH

REVIEWS

Summary: Electrically tunable liquid lenses possess shape-changing principles. We discuss their recent applications, limitations and emerging solutions in enabling high-speed cost-effective 3D live microscopy.

Summary: This Review discusses the structure and function of enigmatic cytoskeletal fibres termed centriolar rootlets, suggesting that they form physical links between subcellular structures to allow collective organelle function.

SHORT REPORT

Summary: Phosphorylation of the F-BAR protein Imp2 within its intrinsically disordered region modulates its localization and function at the contractile ring.

RESEARCH ARTICLES

Summary: LFA-1 and kindlin-3 play unconventional roles in the dynein-dependent and talin-1-independent centripetal transport of actomyosin-associated SLP-76 microclusters and in TCR-proximal signaling pathways.

Summary: Developmentally regulated expression of the miRISC protein GW182 plays an important role in determining dendritic arborization by regulating somatodendritic translation and actin cytoskeletal dynamics.

Summary: We report a comparative analysis of self-assembled spindles and canonical centrosomal spindles in fission yeast, which could clarify the mechanisms underlying acentrosomal meiosis.

Summary: We report a new 3D spheroid model of Epstein–Barr virus-positive and -negative nasopharyngeal carcinoma that resembles advanced and metastatic tumors and has potential use in drug target identification.

Highlighted Article: The Bardet–Biedl syndrome complex component BBS1 regulates proteasome-dependent F-actin clearance from the centrosome to enable its translocation to the T cell immune synapse.

Summary: Replacement of the pore region of polycystin-2 with that of polycystin-2L1 results in wider renal tubules and polycystic kidney disease, thus demonstrating the essential function of its ion channel properties.

Summary: Here, we describe how astrocytes respond differently to stimuli of growth factor during development and the postnatal stage, and the role of the Kidins220 protein in this process.

Summary: Eukaryotic cells need large protein complexes to produce microtubules. We studied the regulation of nuclear and septum-associated microtubule-organizing complexes, and their coordination in one cell.

Highlighted Article: The WNT secretory factor EVI/WLS is ubiquitylated and linked to ER-associated degradation by multiple proteins, providing insight into the link between WNT signalling and the ubiquitin–proteasome system.

Highlighted Article: We report a genetically encoded fluorescent reporter sensitive to all known activators of GPR68, a G-protein-coupled receptor involved in many important physiological functions.

Highlighted Article: There is an unexpected role for the alternative splicing factor PfSR1 in activating the DNA damage response in the human malaria parasite Plasmodium falciparum.

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