Issues
-
Cover image
Cover Image
Cover: ESC-derived postmitotic neurons on day 15 of differentiation, stained for Tubb3 (green). Nuclei are stained with DAPI (blue). Cells were transfected on day 9 of differentiation with microRNA negative control mimics. See article by M. Sauer et al. (jcs257535).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The structural basis of intraflagellar transport at a glance
Summary: A discussion of the current structural understanding of the intraflagellar transport (IFT) and of how IFT trains function as macromolecular machines to assemble the structure of the cilium.
REVIEWS
Molecular models of LINC complex assembly at the nuclear envelope
Summary: A review of recent studies that have shed light on the mechanisms of SUN–KASH interactions, their higher-order assembly, and the molecular mechanisms of force transfer across these complexes.
MyomiRs and their multifaceted regulatory roles in muscle homeostasis and amyotrophic lateral sclerosis
Summary: This Review discusses the contribution of myomiR network dysregulation to myogenic perturbations and muscle atrophy in ALS, as well as the potential for myomiRs as molecular targets of therapeutic strategies.
SHORT REPORTS
Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation
Highlighted Article: ECM stiffness-sensitive expression of lamellipodin promotes cellular stiffness, cyclin expression and cell proliferation in mouse embryonic fibroblasts.
The Cajal body protein coilin is a regulator of the miR-210 hypoxamiR and influences MIR210HG alternative splicing
Summary: Coilin, the Cajal body marker protein, plays an important role in the biogenesis of a microRNA, miR-210, that is responsive to hypoxia. The host gene for miR-210, MIR210HG, is alternatively spliced.
RESEARCH ARTICLES
Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a
Summary: The central apparatus is essential for motility of ‘9+2’ cilia. The conserved proteins FAP70, FAP65 and FAP147 are components of the previously uncharacterized central apparatus projection C2a.
Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission
Highlighted Article: During cytokinesis, Rab11FIP1 localizes to the intercellular bridge where it maintains Rab35, which in turn removes the excess actin formed during membrane ingression thus promoting abscission.
14-3-3 and erlin proteins differentially interact with RIPK2 complexes
Summary: RIPK2 forms dynamic complexes with erlin-1, erlin-2 and 14-3-3 proteins upon bacterial activation of NOD1.
A hub-and-spoke nuclear lamina architecture in trypanosomes
Summary: The arrangement of the lamina in trypanosomatids has architectural differences to the metazoan system.
Kv2 channel–AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking
Summary: All three AMIGO family members act as auxiliary subunits of Kv2.1 and Kv2.2 K+ channels, and assembly of AMIGOs with either Kv2 improves AMIGO trafficking and alters channel function.
RPA facilitates rescue of keratinocytes from UVB radiation damage through insulin-like growth factor-I signalling
Summary: A functional RPA is indispensable for IGF-I-mediated keratinocyte rescue post-UVBR through the regulation of damage responses, cell cycle progression, photoproduct excision and survival pathways.
The miR-26 family regulates neural differentiation-associated microRNAs and mRNAs by directly targeting REST
Summary: MicroRNAs of the miR-26 family trigger molecular events that are essential for neurogenesis by regulating the REST complex, setting in train a neuronal gene expression program.
TOOLS AND RESOURCES
Automated morphometric analysis with SMorph software reveals plasticity induced by antidepressant therapy in hippocampal astrocytes
Highlighted Article: The development of a software tool, SMorph, which performs automated morphometric analysis of cells in the brain. We show structural plasticity in astrocytes after antidepressant treatment.
CORRECTION
Call for papers - Cilia and Flagella: from Basic Biology to Disease

We are welcoming submissions for our upcoming special issue: Cilia and Flagella: from Basic Biology to Disease. This issue will be coordinated by two Guest Editors: Pleasantine Mill (University of Edinburgh) and Lotte Pedersen (University of Copenhagen). Submission deadline: 1 March 2025.
About us

Our publisher, The Company of Biologists, turns 100 this year. Read about the history of the Company and find out what Sarah Bray, our Chair of the Board of Directors, has to say.
Biologists @ 100 - join us in Liverpool in March 2025

We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register your interest to join us in March 2025 in Liverpool, UK. The final deadline for registration is 28 February 2025.
Introducing our new Associate Editors

In this Editorial, JCS Editor-in-Chief Michael Way welcomes five new Associate Editors to the JCS team. These Associate Editors will expand our support for the wider cell biology community and handle articles in immune cell biology, proteostasis, imaging and image analysis, plant cell biology, and stem cell biology and modelling.
How to investigate GPCR signalling in cells

Abigail Pearce and colleagues provide a critical overview of new, state-of-the-art approaches used to quantitatively study G protein-coupled receptor signalling in cells.
JCS-FocalPlane Training Grants

Early-career researchers - working in an area covered by JCS - who would like to attend a microscopy training course, please apply. Deadline dates for 2025 applications: 7 March 2025 (decision by week commencing 21 April 2025) and 6 June 2025 (decision by week commencing 28 July 2025).