CELL SCIENTISTS TO WATCH
Summary: This Review discusses the content and function of extracellular vesicles released from bacteria and from host cells infected with bacteria, comparing Mycobacterium, Listeria and Salmonella pathogens.
Summary: This Review highlights the roles of serotonylation in physiology and diseases, and provides perspectives and insights regarding the pharmacological interventions to ameliorate serotonylation for disease treatment.
Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomyces cerevisiae
Summary: Impaired mitophagy leads to a decrease in cellular SAM and spermidine levels, which in turn causes an impaired cytoprotective nitric oxide response otherwise necessary for heat stress tolerance.
Summary: KIF1BP interacts at midbody with citron kinase and is essential for correct cytokinesis. KIF1BP regulates the level and localization of chromosome passenger complex, KIF23 and KIF14 at midbody.
Summary: Rab11a and Rab11b, as well their effector Sec15, are required for lysosome exocytosis, and the Rab3a guanine nucleotide exchange factor GRAB is essential for this process.
Summary: Increasing expression of IFN7, a crucial mediator of innate immunity, over the course of adult life is mechanistically correlated with aging-like changes to amino acid metabolism and mitochondrial fitness.
YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ERα
Summary: Using tamoxifen-resistant breast cancer patient tissues, clinical datasets and an in vitro model of tamoxifen resistance, we identified CTGF and Cyr61 as negative regulators of ERα, which induces tamoxifen-resistance.
Amyloid-β oligomers block lysosomal targeting of miRNPs to prevent miRNP recycling and target repression in glial cells
Summary: Amyloid-β oligomer perturbs endosome maturation and subsequent fusion with lysosomes, which is important for miRNP recycling and binding with target mRNAs to suppress proinflammatory cytokine production.
Summary: Trim9 and Klp61F contribute to a quality control mechanism near nucleation sites that promotes growth of new microtubules in parallel to existing ones.
Urokinase-type plasminogen activator-mediated crosstalk between N-cadherin and β-catenin promotes wound healing
Summary: Urokinase-type plasminogen activator (uPA) triggers a switch from N-cadherin-induced cell adhesion to β-catenin cell signaling that promotes astrocytic wound healing.
The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1γ by intracellular retention and cell surface masking
Summary: MCMV immunoevasin gp40 inhibits the NKG2D-activating ligand RAE-1γ by intracellular retention that depends on the p24 member TMED10, and additionally by masking it at the cell surface.
Summary: Prion-like p53 amyloids impart oncogenic properties to non-cancerous cells, leading to tumorigenesis, and can therefore play a vital role in cancer initiation.
Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity
Summary: Identification of cellular systems that impinge on protein homeostasis during arsenite stress in yeast, showing that transcriptional and translational control is central for mitigating protein aggregation and toxicity.