Issues
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Cover image
Cover Image
Cover: Perturbation of endosome maturation affects microRNA activity in glial cells exposed to amyloid-β. C6 glioblastoma cells were transiently transfected with YFP–Endo, which labels early endosomes (green), and indirect immunofluorescence was used to detect Rab7a, a marker of late endosomes (red). β-tubulin (purple) was stained to mark the microtubule cytoskeleton. The 3D surface reconstruction of early endosomes, late endosomes and microtubules reveals the distribution of endosomes in a glioblastoma cell, with interaction sites between early endosomes and late endosomes shown in yellow. See article by D. De and S. N. Bhattacharyya (jcs258360).
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RESEARCH HIGHLIGHTS
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REVIEWS
Bacteria- and host-derived extracellular vesicles – two sides of the same coin?
Summary: This Review discusses the content and function of extracellular vesicles released from bacteria and from host cells infected with bacteria, comparing Mycobacterium, Listeria and Salmonella pathogens.
The physiology, pathology and potential therapeutic application of serotonylation
Summary: This Review highlights the roles of serotonylation in physiology and diseases, and provides perspectives and insights regarding the pharmacological interventions to ameliorate serotonylation for disease treatment.
SHORT REPORT
Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomyces cerevisiae
Summary: Impaired mitophagy leads to a decrease in cellular SAM and spermidine levels, which in turn causes an impaired cytoprotective nitric oxide response otherwise necessary for heat stress tolerance.
RESEARCH ARTICLES
Goldberg–Shprintzen syndrome protein KIF1BP is a CITK interactor implicated in cytokinesis
Summary: KIF1BP interacts at midbody with citron kinase and is essential for correct cytokinesis. KIF1BP regulates the level and localization of chromosome passenger complex, KIF23 and KIF14 at midbody.
Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB
Summary: Rab11a and Rab11b, as well their effector Sec15, are required for lysosome exocytosis, and the Rab3a guanine nucleotide exchange factor GRAB is essential for this process.
Interferon regulatory factor 7 impairs cellular metabolism in aging adipose-derived stromal cells
Highlighted Article: Increasing expression of IFN7, a crucial mediator of innate immunity, over the course of adult life is mechanistically correlated with aging-like changes to amino acid metabolism and mitochondrial fitness.
YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ERα
Summary: Using tamoxifen-resistant breast cancer patient tissues, clinical datasets and an in vitro model of tamoxifen resistance, we identified CTGF and Cyr61 as negative regulators of ERα, which induces tamoxifen-resistance.
Amyloid-β oligomers block lysosomal targeting of miRNPs to prevent miRNP recycling and target repression in glial cells
Summary: Amyloid-β oligomer perturbs endosome maturation and subsequent fusion with lysosomes, which is important for miRNP recycling and binding with target mRNAs to suppress proinflammatory cytokine production.
Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules
Summary: Trim9 and Klp61F contribute to a quality control mechanism near nucleation sites that promotes growth of new microtubules in parallel to existing ones.
Urokinase-type plasminogen activator-mediated crosstalk between N-cadherin and β-catenin promotes wound healing
Summary: Urokinase-type plasminogen activator (uPA) triggers a switch from N-cadherin-induced cell adhesion to β-catenin cell signaling that promotes astrocytic wound healing.
The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1γ by intracellular retention and cell surface masking
Summary: MCMV immunoevasin gp40 inhibits the NKG2D-activating ligand RAE-1γ by intracellular retention that depends on the p24 member TMED10, and additionally by masking it at the cell surface.
Direct evidence of cellular transformation by prion-like p53 amyloid infection
Summary: Prion-like p53 amyloids impart oncogenic properties to non-cancerous cells, leading to tumorigenesis, and can therefore play a vital role in cancer initiation.
Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity
Summary: Identification of cellular systems that impinge on protein homeostasis during arsenite stress in yeast, showing that transcriptional and translational control is central for mitigating protein aggregation and toxicity.
JCS fast-track option
Have a paper that has been reviewed elsewhere? JCS is pleased to consider such manuscripts for fast-tracked decision making. Send us your manuscript together with the full set of reviews and decision letters, and we will make an initial decision within one week.
Special Issue – Cell Biology of Mitochondria
Our special issue on ‘Cell Biology of Mitochondria’ is now complete. Explore this issue and read the Editorial from our Guest Editors Ana J. García-Sáez and Heidi McBride.
Save the date – Imaging Cell Dynamics
We are delighted to announce that we will be hosting a 2026 Imaging Cell Dynamics meeting. This meeting will provide a unique opportunity to bring together experts working at the interface between cell biology and imaging. Save the date for 11-14 May 2026 and register for more information.
Origin and evolution of mitochondrial inner membrane composition
In this Review, Kailash Venkatraman and colleagues provide an examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialisation of the mitochondrial lipidome.
Resolution in super-resolution microscopy
Super-resolution microscopy (SRM) has emerged as a powerful tool for biological discovery. In this Perspective, Kirti Prakash and colleagues compile expert opinions on crucial, yet often overlooked, aspects of SRM that are essential for maximising its benefits and advancing the field.
