Issues

Summary: This Review discusses the content and function of extracellular vesicles released from bacteria and from host cells infected with bacteria, comparing Mycobacterium, Listeria and Salmonella pathogens.

Summary: This Review highlights the roles of serotonylation in physiology and diseases, and provides perspectives and insights regarding the pharmacological interventions to ameliorate serotonylation for disease treatment.

Summary: Impaired mitophagy leads to a decrease in cellular SAM and spermidine levels, which in turn causes an impaired cytoprotective nitric oxide response otherwise necessary for heat stress tolerance.

Summary: KIF1BP interacts at midbody with citron kinase and is essential for correct cytokinesis. KIF1BP regulates the level and localization of chromosome passenger complex, KIF23 and KIF14 at midbody.

Summary: Rab11a and Rab11b, as well their effector Sec15, are required for lysosome exocytosis, and the Rab3a guanine nucleotide exchange factor GRAB is essential for this process.

Highlighted Article: Increasing expression of IFN7, a crucial mediator of innate immunity, over the course of adult life is mechanistically correlated with aging-like changes to amino acid metabolism and mitochondrial fitness.

Summary: Using tamoxifen-resistant breast cancer patient tissues, clinical datasets and an in vitro model of tamoxifen resistance, we identified CTGF and Cyr61 as negative regulators of ERα, which induces tamoxifen-resistance.

Summary: Amyloid-β oligomer perturbs endosome maturation and subsequent fusion with lysosomes, which is important for miRNP recycling and binding with target mRNAs to suppress proinflammatory cytokine production.

Summary: Trim9 and Klp61F contribute to a quality control mechanism near nucleation sites that promotes growth of new microtubules in parallel to existing ones.

Summary: Urokinase-type plasminogen activator (uPA) triggers a switch from N-cadherin-induced cell adhesion to β-catenin cell signaling that promotes astrocytic wound healing.

Summary: MCMV immunoevasin gp40 inhibits the NKG2D-activating ligand RAE-1γ by intracellular retention that depends on the p24 member TMED10, and additionally by masking it at the cell surface.

Summary: Prion-like p53 amyloids impart oncogenic properties to non-cancerous cells, leading to tumorigenesis, and can therefore play a vital role in cancer initiation.

Summary: Identification of cellular systems that impinge on protein homeostasis during arsenite stress in yeast, showing that transcriptional and translational control is central for mitigating protein aggregation and toxicity.