Issues
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Cover image
Cover Image
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Close ModalCover: B16-F1 mouse melanoma cell migrating on laminin and expressing EGFP-tagged actin prominently accumulating in protruding lamellipodia at the cell front. The image is a composite of four different time points displayed in distinct colors. See article by G. Dimchev et al. (jcs239020).
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RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
MEETING REPORT
CELL SCIENCE AT A GLANCE
Bacterial cell division at a glance
Summary: This Cell Science at a Glance article provides an overview of the initial stages of cytokinetic ring assembly, dynamics and activation during bacterial cell division.
REVIEW
HECT E3 ubiquitin ligases – emerging insights into their biological roles and disease relevance
Summary: This comprehensive Review discusses our current understanding on the biological roles of the HECT E3 ubiquitin ligases in the cell and how they contribute to disease development.
RESEARCH ARTICLES
Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway in S. cerevisiae
Summary: A differentiation-type MAPK pathway in yeast regulates polarity establishment during budding, which sensitizes this essential cellular process to external cues.
AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture
Summary: A ‘multi-omic’ approach identified a metabolic state-dependent lethality in cancer cells, namely the reduced ability of cells with constitutive activation of PI3K/AKT to switch between glycolysis and respiration.
Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation
Summary: Genetic ablation of the prominent actin- and VASP-binding protein lamellipodin, combined with software-aided protrusion analysis, uncovers mechanistic insights into its cellular function during cell migration.
Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection
Highlighted Article: Leishmania effluxes host ATP generated from increased glycolysis, which is converted into extracellular adenosine to create an anti-inflammatory milieu within infected cells via receptor-mediated signalling.
ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis
Summary: ADAMTS-1 and syndecan-4 collaborate to regulate cell adhesion, migration and integrin α5 trafficking, and to sequester VEGFA164, inhibiting angiogenesis.
Drosophila Prp40 localizes to the histone locus body and regulates gene transcription and development
Summary: Drosophila Prp40 is essential for viability and development, localizes to the histone locus body, and plays a novel role in regulation of histone gene transcription.
A novel benzodiazepine derivative that suppresses microtubule dynamics and impairs mitotic progression
Highlighted Article: Identification of a novel promising anti-mitotic drug, a 2,3-benzodiazepine-4 derivative, with unique properties, altering microtubule growth and mitotic spindle organization.
Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line
Summary: Repression by PUM proteins, known post-transcriptional regulators, might represent one of the mechanisms influencing KIF18A level in controlling proliferation, cell cycle and apoptosis in a human germ cell line.
Rab10, Crag and Ehbp1 regulate the basolateral transport of Na+K+ATPase in Drosophila photoreceptors
Summary: Crag, Rab10 and Ehbp1 localize to the trans-side of Golgi stacks and regulate Na+K+ATPase transport from Golgi stacks to the basolateral membrane, presumably on the vesicle-budding process in Drosophila photoreceptors.
TOOLS AND RESOURCES
CTRL – a label-free artificial intelligence method for dynamic measurement of single-cell volume
Summary: A machine learning algorithm can predict the 3D mammalian cell volume to accurate quantify cell volume and cell growth trajectories in standard cell imaging conditions.
AstroDot – a new method for studying the spatial distribution of mRNA in astrocytes
Summary: AstroDot is a new method for studying the spatial distribution of mRNA ex vivo in complex brain cells, such as astrocytes and microglia, in physiological and pathological conditions.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Call for papers: Cell and Tissue Polarity
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We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Journal of Cell Science a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
FocalPlane Image Competition 2023
FocalPlane’s 2023 image competition is underway, in celebration of the community site’s third birthday. Click here for submission details and information on how to showcase your favourite image.
