Issues

Summary: This Review highlights novel advancements in the involvement of small extracellular vesicles (EVs) as propagators of neuropathology, biomarkers and potential therapeutics in neurodegenerative diseases.

Summary: A Review of the mechanical tuning of growth factor signaling through crosstalk and interaction with mechanosensitive integrin cell adhesive receptors.

Summary: The NLRP3 inflammasome is a critical mediator of inflammation subject to dense regulatory networks to prevent erroneous inflammation. Here, we review recent advances into this exciting area of research.

Summary: The fission yeast dual PH domain-containing protein Opy1 binds PI(4,5)P2 and senses this lipid in the plasma membrane. Unlike related proteins, Opy1 binds but does not regulate phosphatidylinositol 4-phosphate 5-kinase.

Summary: We report the localization and function of the Cdc48 chaperone at intranuclear protein quality control sites in yeast, where it regulates the stability of the Hsh155 splicing factor.

Summary: An aggregation–dissolution model for the temporal and spatial control of mRNA translation is found for Pum1-mediated control in mouse oocytes.

Summary: Inhibition of BMP signalling by targeting ALK2 and ALK3 reduces OA hypertrophic features in an OA micro-cartilage model, while maintaining the capacity of the cells to produce cartilage-specific proteins.

Summary: Dopamine receptor D1 agonism promotes degradation of collagen I in lung fibroblasts by enhancing cathepsin K expression and activation.

Highlighted Article: Expression and mutagenic analyses demonstrated that ssc-miR-21-5p impedes PDCD4 and, therefore, the phosphorylation of AKT which affected the functions of endometrial epithelial cells.

Summary: Altered mitochondrial energetics plays a more decisive role than morphology in determining tumor-like growth in a fly tumor model caused by elevated Homeodomain-interacting protein kinase.

Summary: SMARCA2, a candidate gene for sow reproductive traits, controls porcine granulosa cell apoptosis and is regulated by the NORFA–miR-29c signaling pathway, a novel regulatory pathway associated with female fertility.

Highlighted Article: Temporal analysis of human neoplasia identifies PAR3 as a critical regulator of E-cadherin-mediated cell adhesion and oriented cell division during initial human SCC development.

Summary: AGS3 activates Gαi1 and results in the transport of TMED7-positive cargo containing Cdh1 to the cell-contact surface by reinforcing the dynamic trans-Golgi network in the early mouse embryo.

Highlighted Article: Homologous chromosomes recombine and synapse during meiotic prophase. Aurora kinase B and C are important to coordinate chromosome desynapsis and segregation during mouse and human spermatogenesis.