CELL SCIENTISTS TO WATCH
Summary: In this review, we describe how errors in membrane protein biogenesis can trigger co-translational degradation that employs machinery of the ribosome-associated quality control pathway.
Summary: In this Review, we discuss molecular interactions between the brassinosteroid and immune signalling pathways, which contribute to the growth–defence trade-off in plants.
Summary: This Review discusses the role of accessory proteins in regulating the stability, localisation and activity of the zDHHC family of S-acyltransferases.
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53
Summary: IKKα functions as a coactivator for CHK1- and p300/CBP-dependent p53 acetylation, which leads to autophagy induction and feedback degradation of IKKα during the arsenite cytotoxic response.
Summary: Mutagenic and cytological analyses allow the characterization of proteins that are crucial for the bouquet-like chromosome arrangement in Tetrahymena and propose that centromere clustering is important for pairing.
Stable tug-of-war between kinesin-1 and cytoplasmic dynein upon different ATP and roadblock concentrations
Highlighted Article: Changing the number of active dynein and kinesin motors can strongly influence bidirectional motility on microtubules while a stable tug-of-war persists upon changing ATP and roadblock concentrations.
Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway
Summary: Mitochondrial dysfunction triggers the expression of osteoarthritis-related catabolic genes in human chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway.
Phosphorylation and dephosphorylation of Ser852 and Ser889 control the clustering, localization and function of PAR3
Highlighted Article: Phosphorylation and dephosphorylation regulate clustering of PAR3, a cell polarity-regulating factor, and this clustering affects the localization of PAR3 and cell–cell junctions.
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages
Summary: BCAT1 controls mitochondrial metabolism independently of its transamination role in activated human macrophages.
TOOLS AND RESOURCES
An image analysis method to survey the dynamics of polar protein abundance in the regulation of tip growth
Summary: Large-scale time-lapse analysis of individual tip growth and polar factor abundance in yeast and filamentous fungi reveals limits to tip surface expansion rates that are independent of local remodeling activity.
Summary: Analysis of cell shape and movement from 3D time-lapses is currently very challenging. Here, we develop Cell Tracking Profiler and use it to examine RhoA and myosin II control of muscle stem cell behaviour during zebrafish regeneration.