Issues
-
Cover image
Cover Image
Cover: PAR3, an evolutionarily conserved cell polarity-regulating factor, is known to form protein clusters. PAR3 cluster formation is important for its accumulation at specific sites in polarized cells. The study demonstrates that phosphorylation of Ser852 and Ser889 inhibit clustering of PAR3 and that the ASPP2–PP1 protein complex dephosphorylates Ser852 of PAR3. In this image, an exogenously expressed Ser852Ala mutant PAR3 (green), ASPP2 (magenta) and nucleus (blue) were visualized through immunofluorescence. ASPP2 accumulated in the PAR3 clusters. Note that these MDCK epithelial cells were cultured in low Ca2+-containing medium to disrupt the cell–cell adhesion. See article by K. Yamashita et al. (jcs244830).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
STICKY WICKETS
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEWS
Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum
Summary: In this review, we describe how errors in membrane protein biogenesis can trigger co-translational degradation that employs machinery of the ribosome-associated quality control pathway.
It takes two to tango – molecular links between plant immunity and brassinosteroid signalling
Summary: In this Review, we discuss molecular interactions between the brassinosteroid and immune signalling pathways, which contribute to the growth–defence trade-off in plants.
Accessory proteins of the zDHHC family of S-acylation enzymes
Summary: This Review discusses the role of accessory proteins in regulating the stability, localisation and activity of the zDHHC family of S-acyltransferases.
SHORT REPORT
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53
Summary: IKKα functions as a coactivator for CHK1- and p300/CBP-dependent p53 acetylation, which leads to autophagy induction and feedback degradation of IKKα during the arsenite cytotoxic response.
RESEARCH ARTICLES
Spatial constraints on chromosomes are instrumental to meiotic pairing
Summary: Mutagenic and cytological analyses allow the characterization of proteins that are crucial for the bouquet-like chromosome arrangement in Tetrahymena and propose that centromere clustering is important for pairing.
Stable tug-of-war between kinesin-1 and cytoplasmic dynein upon different ATP and roadblock concentrations
Highlighted Article: Changing the number of active dynein and kinesin motors can strongly influence bidirectional motility on microtubules while a stable tug-of-war persists upon changing ATP and roadblock concentrations.
Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway
Summary: Mitochondrial dysfunction triggers the expression of osteoarthritis-related catabolic genes in human chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway.
Phosphorylation and dephosphorylation of Ser852 and Ser889 control the clustering, localization and function of PAR3
Highlighted Article: Phosphorylation and dephosphorylation regulate clustering of PAR3, a cell polarity-regulating factor, and this clustering affects the localization of PAR3 and cell–cell junctions.
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages
Summary: BCAT1 controls mitochondrial metabolism independently of its transamination role in activated human macrophages.
TOOLS AND RESOURCES
An image analysis method to survey the dynamics of polar protein abundance in the regulation of tip growth
Summary: Large-scale time-lapse analysis of individual tip growth and polar factor abundance in yeast and filamentous fungi reveals limits to tip surface expansion rates that are independent of local remodeling activity.
Cell Tracking Profiler – a user-driven analysis framework for evaluating 4D live-cell imaging data
Summary: Analysis of cell shape and movement from 3D time-lapses is currently very challenging. Here, we develop Cell Tracking Profiler and use it to examine RhoA and myosin II control of muscle stem cell behaviour during zebrafish regeneration.
Special Issue: Cell Biology of Lipids
-LipidSI.png?versionId=3647)
Lipids are the main component of cellular membranes, but have key roles in many essential cellular processes, as well as structural and signalling functions. Our 2022 special issue showcases the diversity of current research in lipid cell biology.
The special issue includes an interview with Guest Editor James Olzmann. James has also contributed to this lipid droplet wall poster from our sponsor, Cayman Chemical.
Propose a new Workshop
-GSWorkshop.png?versionId=3647)
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
We’re hiring: Community Manager, preLights
-preLights.jpg?versionId=3647)
We are seeking to appoint a new Community Manager to run our preprint highlighting service, preLights. Launched in 2018, this initiative has gained significant attention from researchers and the publishing industry. We are now looking for the right person to join us for the next phase of community building and the site’s growth and development. Please see the full job description for further details.
The application deadline is 20 May 2022.
Essay series: Equity, diversity and inclusion in cell biology
-EssaySeries.png?versionId=3647)
The JCS Essay Series is an initiative to help showcase and provide a platform for voices in the field of cell biology. The first topic we covered was 'Equity, diversity and inclusion in cell biology', and the winning and runner up essays are now available to read.
FocalPlane Network launched
-FocalPlaneNetworkLaunch.png?versionId=3647)
We are excited to announce the launch of the FocalPlane Network, an international directory of microscopists. The idea behind the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.