Issues

Summary: In this review, we describe how errors in membrane protein biogenesis can trigger co-translational degradation that employs machinery of the ribosome-associated quality control pathway.

Summary: In this Review, we discuss molecular interactions between the brassinosteroid and immune signalling pathways, which contribute to the growth–defence trade-off in plants.

Summary: This Review discusses the role of accessory proteins in regulating the stability, localisation and activity of the zDHHC family of S-acyltransferases.

Summary: IKKα functions as a coactivator for CHK1- and p300/CBP-dependent p53 acetylation, which leads to autophagy induction and feedback degradation of IKKα during the arsenite cytotoxic response.

Summary: Mutagenic and cytological analyses allow the characterization of proteins that are crucial for the bouquet-like chromosome arrangement in Tetrahymena and propose that centromere clustering is important for pairing.

Highlighted Article: Changing the number of active dynein and kinesin motors can strongly influence bidirectional motility on microtubules while a stable tug-of-war persists upon changing ATP and roadblock concentrations.

Summary: Mitochondrial dysfunction triggers the expression of osteoarthritis-related catabolic genes in human chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway.

Highlighted Article: Phosphorylation and dephosphorylation regulate clustering of PAR3, a cell polarity-regulating factor, and this clustering affects the localization of PAR3 and cell–cell junctions.

Summary: BCAT1 controls mitochondrial metabolism independently of its transamination role in activated human macrophages.

Summary: Large-scale time-lapse analysis of individual tip growth and polar factor abundance in yeast and filamentous fungi reveals limits to tip surface expansion rates that are independent of local remodeling activity.

Summary: Analysis of cell shape and movement from 3D time-lapses is currently very challenging. Here, we develop Cell Tracking Profiler and use it to examine RhoA and myosin II control of muscle stem cell behaviour during zebrafish regeneration.