Issues
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Cover image
Cover Image
Cover: PAR3, an evolutionarily conserved cell polarity-regulating factor, is known to form protein clusters. PAR3 cluster formation is important for its accumulation at specific sites in polarized cells. The study demonstrates that phosphorylation of Ser852 and Ser889 inhibit clustering of PAR3 and that the ASPP2–PP1 protein complex dephosphorylates Ser852 of PAR3. In this image, an exogenously expressed Ser852Ala mutant PAR3 (green), ASPP2 (magenta) and nucleus (blue) were visualized through immunofluorescence. ASPP2 accumulated in the PAR3 clusters. Note that these MDCK epithelial cells were cultured in low Ca2+-containing medium to disrupt the cell–cell adhesion. See article by K. Yamashita et al. (jcs244830).
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RESEARCH HIGHLIGHTS
STICKY WICKETS
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CELL SCIENTISTS TO WATCH
REVIEWS
Ribosome-associated quality control of membrane proteins at the endoplasmic reticulum
Summary: In this review, we describe how errors in membrane protein biogenesis can trigger co-translational degradation that employs machinery of the ribosome-associated quality control pathway.
It takes two to tango – molecular links between plant immunity and brassinosteroid signalling
Summary: In this Review, we discuss molecular interactions between the brassinosteroid and immune signalling pathways, which contribute to the growth–defence trade-off in plants.
Accessory proteins of the zDHHC family of S-acylation enzymes
Summary: This Review discusses the role of accessory proteins in regulating the stability, localisation and activity of the zDHHC family of S-acyltransferases.
SHORT REPORT
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53
Summary: IKKα functions as a coactivator for CHK1- and p300/CBP-dependent p53 acetylation, which leads to autophagy induction and feedback degradation of IKKα during the arsenite cytotoxic response.
RESEARCH ARTICLES
Spatial constraints on chromosomes are instrumental to meiotic pairing
Summary: Mutagenic and cytological analyses allow the characterization of proteins that are crucial for the bouquet-like chromosome arrangement in Tetrahymena and propose that centromere clustering is important for pairing.
Stable tug-of-war between kinesin-1 and cytoplasmic dynein upon different ATP and roadblock concentrations
Highlighted Article: Changing the number of active dynein and kinesin motors can strongly influence bidirectional motility on microtubules while a stable tug-of-war persists upon changing ATP and roadblock concentrations.
Mitochondrial dysfunction triggers a catabolic response in chondrocytes via ROS-mediated activation of the JNK/AP1 pathway
Summary: Mitochondrial dysfunction triggers the expression of osteoarthritis-related catabolic genes in human chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway.
Phosphorylation and dephosphorylation of Ser852 and Ser889 control the clustering, localization and function of PAR3
Highlighted Article: Phosphorylation and dephosphorylation regulate clustering of PAR3, a cell polarity-regulating factor, and this clustering affects the localization of PAR3 and cell–cell junctions.
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages
Summary: BCAT1 controls mitochondrial metabolism independently of its transamination role in activated human macrophages.
TOOLS AND RESOURCES
An image analysis method to survey the dynamics of polar protein abundance in the regulation of tip growth
Summary: Large-scale time-lapse analysis of individual tip growth and polar factor abundance in yeast and filamentous fungi reveals limits to tip surface expansion rates that are independent of local remodeling activity.
Cell Tracking Profiler – a user-driven analysis framework for evaluating 4D live-cell imaging data
Summary: Analysis of cell shape and movement from 3D time-lapses is currently very challenging. Here, we develop Cell Tracking Profiler and use it to examine RhoA and myosin II control of muscle stem cell behaviour during zebrafish regeneration.
Imaging Cell Architecture and Dynamics

We are now welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Submission deadline: 1 March 2024.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'

Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Early-bird deadline is 19 January 2024.
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Sustainable Conferencing Initiative

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